Biomarkers to predict staging and treatment response in opioid dependence: A narrative review - Archive ouverte HAL
Article Dans Une Revue Drug Development Research Année : 2021

Biomarkers to predict staging and treatment response in opioid dependence: A narrative review

Résumé

Opioid use disorder is a devastating disorder with a high burden in terms of overdose mortality, with an urgent need for more personalized prevention or therapeutic interventions. For this purpose, the description and validation of biological measures of staging or treatment response is a highly active research field. We conducted a narrative review on the pathophysiology of opioid use disorder to propose staging of the disease and search for research studies proposing or demonstrating the predictive value of biomarkers. We propose a IV stage description of opioid use disorder, from (I) vulnerability stage to (II) disease progression, (III) constituted opioid dependence and were several type of treatments can be applied, to the reach a (IV) modified health state. We classified biomarkers studies according to the stage of the disorder they were intended to predict, and to the three categories of methods they used: anatomical and functional aspects of the brain, genetic/transcriptomic/epigenetic studies, and lastly biomarkers of systemic modifications associated with opioid use disorder, especially regarding the immune system. Most studies predicting Stage III that we reviewed collected data from small samples sizes and were cross-sectional association studies comparing opioid dependent patients and control groups. Pharmacogenetic biomarkers are proposed to predict treatment response. Future research should now emphasize prospective studies, replication in independent samples, and predictive value calculation of each biomarker. The most promising results are multimodal evaluations to be able to measure the state of the brain reward system in living individuals.
Fichier principal
Vignette du fichier
Vorspan et al 2020 Drug Dev Res.pdf (1.72 Mo) Télécharger le fichier
Origine Publication financée par une institution

Dates et versions

hal-03123197 , version 1 (05-10-2022)

Identifiants

Citer

Florence Vorspan, Cynthia Marie-Claire, Frank Bellivier, Vanessa Bloch. Biomarkers to predict staging and treatment response in opioid dependence: A narrative review. Drug Development Research, 2021, ⟨10.1002/ddr.21789⟩. ⟨hal-03123197⟩

Collections

INSERM UP-SANTE

Altmetric

Partager

More