Impact on testicular function of a single ablative activity of 3.7 GBq radioactive iodine for differentiated thyroid carcinoma
Résumé
Thirty six patients were included in the study. At V0, all patients had normal gonadal function. At V3, FSH median levels were significantly increased as compared to V0, respectively 9 UI/l±4.8 (N: 3–7 UI/l) versus 4 UI/l±3 (P<0.0001). Between V3 and V13, FSH levels decreased but remained higher than baseline levels. Inhibin B median levels decreased significantly at V3 (P<0.0001) and returned to V0 levels at V13. LH and T levels were not modified at V3 or V13.
Median sperm concentration significantly decreased at V3 as compared to V0 (20 vs 48 million/ml; P<0.0001) and returned to V0 levels at V13. In parallel, a statistically significant decrease in sperm morphology was observed at V3. Sperm mobility and DNA fragmentation were not modified after RAI. However sperm chromosomal abnormalities were increased at V3 (P<0.0005) and V13 (P<0.01), as compared to V0.