β2-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ - Archive ouverte HAL
Article Dans Une Revue Nature Chemical Biology Année : 2017

β2-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ

Jingming Chen
  • Fonction : Auteur
Masaki Noda
  • Fonction : Auteur
Juan Taboas
  • Fonction : Auteur
Jean-Pierre Vilardaga

Résumé

Cells express several G-protein-coupled receptors (GPCRs) at their surfaces, transmitting simultaneous extracellular hormonal and chemical signals into cells. A comprehensive understanding of mechanisms underlying the integrated signaling response induced by distinct GPCRs is thus required. Here we found that the b2-adrenergic receptor, which induces a short cAMP response, prolongs nuclear cAMP and protein kinase A (PKA) activation by promoting endosomal cAMP production in parathyroid hormone (PTH) receptor signaling through the stimulatory action of G protein G beta gamma subunits on adenylate cyclase type 2.

Dates et versions

hal-03117157 , version 1 (20-01-2021)

Identifiants

Citer

Frédéric Jean-Alphonse, Vanessa Wehbi, Jingming Chen, Masaki Noda, Juan Taboas, et al.. β2-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ. Nature Chemical Biology, 2017, 13 (3), pp.259-261. ⟨10.1038/nchembio.2267⟩. ⟨hal-03117157⟩
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