In situ isobaric lipid mapping by MALDI-ion mobility separation-mass spectrometry imaging - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Mass Spectrometry Année : 2020

In situ isobaric lipid mapping by MALDI-ion mobility separation-mass spectrometry imaging

Janina Oetjen
Arnaud Chaumot

Résumé

The highly diverse chemical structures of lipids make their analysis directly from biological tissue sections extremely challenging. Here, we report the in situ mapping and identification of lipids in a freshwater crustaceanGammarus fossarumusing matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) in combination with an additional separation dimension using ion mobility spectrometry (IMS). The high-resolution trapped ion mobility spectrometry (TIMS) allowed efficient separation of isobaric/isomeric lipids showing distinct spatial distributions. The structures of the lipids were further characterized by MS/MS analysis. It is demonstrated that MALDI MSI with mobility separation is a powerful tool for distinguishing and localizing isobaric/isomeric lipids.
Fichier principal
Vignette du fichier
jms.4531.pdf (1004.75 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03113280 , version 1 (03-05-2024)

Identifiants

Citer

Tingting Fu, Janina Oetjen, Manuel Chapelle, Alexandre Verdu, Matthias Szesny, et al.. In situ isobaric lipid mapping by MALDI-ion mobility separation-mass spectrometry imaging. Journal of Mass Spectrometry, 2020, 55 (9), pp.e4531. ⟨10.1002/jms.4531⟩. ⟨hal-03113280⟩
87 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More