Cell therapy of burns
Résumé
Severe burns remain a life threatening local and general inflammatory disease with often heavy sequelae, despite remarkable progress in their treatment in the last three decades. Cultured epidermal autografts, the first and still up-to-date cell therapy of burns, played a key role in that progress, and their drawbacks should be reduced with cultured dermal-epidermal substitutes. This review focuses on what could be the next major breakthrough in cell therapy of burns: mesenchymal stromal cells (MSCs). After summarizing current knowledge, including our own clinical experience, about MSCs in the pioneer field of cell therapy in radiation-induced burns, we discuss the strong rationale supporting the potential interest of MSCs in the treatment of thermal burns, including limited but promising pre-clinical and clinical data in wound healing and other acute inflammatory diseases. © 2012 The authors and IOS Press. All rights reserved.
Mots clés
5' nucleotidase
angiopoietin 1
C reactive protein
CD14 antigen
CD34 antigen
CD45 antigen
collagen type 1
collagen type 6
endoglin
fibronectin
Thy 1 antigen
vasculotropin
adipocyte
angiogenesis
antigen expression
article
burn
cartilage cell
cell adhesion
cell culture
cell differentiation
cell lineage
cell therapy
cell transdifferentiation
disease severity
human
keratinocyte
mesenchymal stem cell transplantation
osteoblast
paracrine signaling
protein expression
radiation injury
skin graft
skin transplantation
tissue regeneration
tissue repair
wound healing