We report observations by the Mars Climate Sounder showing strong diurnal variations in temperature and the vertical dust distribution during the 2018 (Mars Year 34) global dust event. The temperature field shows weak diurnal tidal activity at equatorial latitudes but a strong diurnal tide in middle to high latitudes with a maximum amplitude of 29 K in the lower atmosphere of the south polar region. The diurnal variability of dust is small in the equatorial region and increases toward higher latitudes. At middle and low latitudes, comparable dust amounts are found about 5–10 km higher in the atmosphere on the dayside than on the nightside. The dust reaches the highest altitudes in the late afternoon and is found at the lowest altitudes in the late night. In the southern high latitudes a persistent cold air mass with low dust content is identified on the nightside of the planet centered at 3–6 a.m. local time. The observed variations are well represented by model simulations with the Laboratoire de Météorologie Dynamique General Circulation Model. Comparisons between data and model results suggest that the diurnal variations in the dust are largely driven by the meridional circulation exhibiting diurnal tidal variations. The model results show that the compact air mass in the south polar region has a high potential vorticity, supporting its interpretation as a remnant of the southern polar vortex, which is forced toward the nightside of the planet due to the enhanced diurnal tide during the global dust event.