Characteristics of pruritus in bullous pemphigoid and impact on quality of life: A prospective cohort study
C. Briand
(1)
,
G. Gourier
(1)
,
F. Poizeau
(2)
,
L. Jelti
(3)
,
M. Bachelerie
(4)
,
G. Quéreux
(5)
,
G. Jeudy
(6)
,
M. Acquitter
,
S. Ingen-Housz-Oro
(7)
,
F. Caux
(8)
,
C. Prost
(8)
,
A.-S. Darriguade
(9)
,
D. Heron Mermin
(9)
,
E. Mahé
(10)
,
C. Picart Dahan
(11)
,
M.-A. Richard
(12)
,
C.J. Clerc
(13)
,
C. Salle de Chou
(14)
,
J. Plée
(15)
,
C. Abasq-Thomas
(1)
,
L. Misery
(1)
,
E. Brenaut
(1)
1
CHRU Brest -
Centre Hospitalier Régional Universitaire de Brest
2 REPERES - Recherche en Pharmaco-épidémiologie et Recours aux Soins
3 CHU Rouen
4 CHU Clermont-Ferrand
5 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
6 CHU Dijon
7 CHU Henri Mondor [Créteil]
8 Hôpital Avicenne [AP-HP]
9 CHU Bordeaux
10 Centre Hospitalier Victor Dupouy
11 CIC - CHU Bichat
12 CHU Marseille
13 CH Georges Renon Niort - Centre Hospitalier Georges Renon [Niort]
14 AP-HP - Hopital Saint-Louis [AP-HP]
15 CHU Reims - Hôpital universitaire Robert Debré [Reims]
2 REPERES - Recherche en Pharmaco-épidémiologie et Recours aux Soins
3 CHU Rouen
4 CHU Clermont-Ferrand
5 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
6 CHU Dijon
7 CHU Henri Mondor [Créteil]
8 Hôpital Avicenne [AP-HP]
9 CHU Bordeaux
10 Centre Hospitalier Victor Dupouy
11 CIC - CHU Bichat
12 CHU Marseille
13 CH Georges Renon Niort - Centre Hospitalier Georges Renon [Niort]
14 AP-HP - Hopital Saint-Louis [AP-HP]
15 CHU Reims - Hôpital universitaire Robert Debré [Reims]
C. Briand
- Fonction : Auteur
- PersonId : 780419
- ORCID : 0000-0003-0271-9839
- IdRef : 147920760
M. Acquitter
- Fonction : Auteur
C. Prost
- Fonction : Auteur
- PersonId : 968889
- ORCID : 0000-0002-0178-3823
- IdRef : 079508138
E. Mahé
- Fonction : Auteur
- PersonId : 758371
- ORCID : 0000-0001-5780-1827
- IdRef : 081310773
L. Misery
- Fonction : Auteur
- PersonId : 785565
- ORCID : 0000-0001-8088-7059
E. Brenaut
- Fonction : Auteur correspondant
- PersonId : 769625
- ORCID : 0000-0002-0170-5083
Résumé
Pruritus is a common symptom of bullous pemphi-goid (BP), but has been poorly studied. The aim of this study was to analyse the characteristics of pruritus in patients with BP and its impact on their quality of life. A multicentre prospective observational study (in 15 French hospitals) was performed. A total of 60 patients were included, with a mean age of 77.4 years. Pru-ritus occurred daily in 85% of patients, with a mean pruritus intensity of 5.2/10. Tingling sensations were present in 72.4% of patients and burning sensations in 68.9%. Pruritus was exacerbated by stress, fatigue and xerosis. The mean ItchyQol score was 56.2/110 and the mean 5-D Itch Scale score was 16.5/25. The severity of pruritus was not related to age, sex, BP activity score, eosinophilia, or anti-BP230 and anti-BP180 autoantibodies. This study revealed that pruri-tus in BP is poorly tolerated and is an important cause of impaired quality of life. .
Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Characteristics of pruritus in bullous pemphigoid and impact on quality of life: A prospective cohort study
|
Résumé |
en
Pruritus is a common symptom of bullous pemphi-goid (BP), but has been poorly studied. The aim of this study was to analyse the characteristics of pruritus in patients with BP and its impact on their quality of life. A multicentre prospective observational study (in 15 French hospitals) was performed. A total of 60 patients were included, with a mean age of 77.4 years. Pru-ritus occurred daily in 85% of patients, with a mean pruritus intensity of 5.2/10. Tingling sensations were present in 72.4% of patients and burning sensations in 68.9%. Pruritus was exacerbated by stress, fatigue and xerosis. The mean ItchyQol score was 56.2/110 and the mean 5-D Itch Scale score was 16.5/25. The severity of pruritus was not related to age, sex, BP activity score, eosinophilia, or anti-BP230 and anti-BP180 autoantibodies. This study revealed that pruri-tus in BP is poorly tolerated and is an important cause of impaired quality of life. .
|
Auteur(s) |
C. Briand
1
, G. Gourier
1
, F. Poizeau
2
, L. Jelti
3
, M. Bachelerie
4
, G. Quéreux
5
, G. Jeudy
6
, M. Acquitter
, S. Ingen-Housz-Oro
7
, F. Caux
8
, C. Prost
8
, A.-S. Darriguade
9
, D. Heron Mermin
9
, E. Mahé
10
, C. Picart Dahan
11
, M.-A. Richard
12
, C.J. Clerc
13
, C. Salle de Chou
14
, J. Plée
15
, C. Abasq-Thomas
1
, L. Misery
1
, E. Brenaut
1
1
CHRU Brest -
Centre Hospitalier Régional Universitaire de Brest
( 356603 )
- France
2
REPERES -
Recherche en Pharmaco-épidémiologie et Recours aux Soins
( 481484 )
- Université de Rennes 1 / EHESP
- France
3
CHU Rouen
( 300147 )
- 1 rue de Germont 76031 Rouen cedex
- France
4
CHU Clermont-Ferrand
( 300144 )
- France
5
CHU Nantes -
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
( 474972 )
- 1 Place Alexis-Ricordeau, 44000 Nantes
- France
6
CHU Dijon
( 35051 )
- BP1542, 21034 Dijon cedex
- France
7
CHU Henri Mondor [Créteil]
( 366262 )
- Créteil
- France
8
Hôpital Avicenne [AP-HP]
( 300210 )
- 125, rue de Stalingrad 93000 Bobigny
- France
9
CHU Bordeaux
( 300122 )
- 12 rue Dubernat
33400 Talence
- France
10
Centre Hospitalier Victor Dupouy
( 564341 )
- 69, rue du Lieutenant-Colonel Prud'hon,
95107 Argenteuil Cedex
Tél. : 01 34 23 20 35
E-mail : usagers@ch-argenteuil.fr
- France
11
CIC - CHU Bichat
( 2607 )
- Gh Xavier Bichat - Claude Bernard PARIS VII 46, Rue Henri Huchard 75018 PARIS
- France
12
CHU Marseille
( 301298 )
-
- France
13
CH Georges Renon Niort -
Centre Hospitalier Georges Renon [Niort]
( 523558 )
- 40 avenue Charles de Gaulle
BP 70600 - 79021 Niort Cedex
- France
14
AP-HP -
Hopital Saint-Louis [AP-HP]
( 506757 )
- 1 Avenue Claude Vellefaux, 75010 Paris
- France
15
CHU Reims -
Hôpital universitaire Robert Debré [Reims]
( 417765 )
- rue du General Koenig 51090 Reims Cedex
- France
|
Langue du document |
Anglais
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication électronique |
2020-11-02
|
Volume |
100
|
Numéro |
18
|
Page/Identifiant |
1-6
|
Nom de la revue |
|
Date de publication |
2020-11-12
|
Domaine(s) |
|
Mots-clés |
en
5-D Itch Scale, Bullous pemphigoid, Itch, ItchyQol, Pruritus, Quality of life
|
DOI | 10.2340/00015555-3683 |
Pubmed Id | 33135772 |
Origine :
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