Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19
Résumé
Inflammaging constitutes the common factor for comorbidities predisposing to severe COVID-19. Inflammaging leads to T-cell senescence, and immunosenescence is linked to autoimmune manifestations in COVID-19. As in SLE, metabolic dysregulation occurs in T-cells. Targeting this T-cell dysfunction opens the field for new therapeutic strategies to prevent severe COVID-19. Immunometabolism-mediated approaches such as rapamycin, metformin and dimethyl fumarate, may optimize COVID-19 treatment of the elderly and patients at risk for severe disease.
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Omarjee-2020-Immunometabolism at the cornerstone of inflammaging.pdf (1.03 Mo)
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