Cardiac arrhythmias and conduction disorders after breast cancer treatment including radiotherapy: a study based on the French nationwide health database - Archive ouverte HAL Accéder directement au contenu
Communication Dans Un Congrès Année : 2019

Cardiac arrhythmias and conduction disorders after breast cancer treatment including radiotherapy: a study based on the French nationwide health database

Résumé

Introduction: We plan to evaluate whether breast cancer (BC) treatment, including radiotherapy, is associated with an increased risk of cardiac arrhythmias and conduction disorders (ACD) characterized by implantation of pacemaker or defibrillator or hospitalization for rhythm disorders. Methods: Our study is based on the Echantillon Généraliste de Bénéficiaires (EGB), the 1/97 random sample of the French nationwide health database. We identify patients treated for BC between 2008 and 2012 and cases of ACD arising post BC until 2017. The ACD incidence rates according to BC treatment (Surgery±Chemotherapy±Radiotherapy) will be estimated and compared to the national incidence rates estimated from the EGB population. Results: Within an initial cohort of approximately 260 000 women in the EGB, nearly 3000 patients treated for BC. We should detect ~5000 incident cases of ACD in the EGB cohort. The observation of at least 85 incident cases of ACD in the BC subgroup instead of 60 (RR=1.4) will have a statistical power of 80%. Conclusion: The study is ongoing. It will allow quantifying the excess risk of ACD suspected for BC treatment, in particular mediastinal radiotherapy.
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hal-03098809 , version 1 (05-01-2021)

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  • HAL Id : hal-03098809 , version 1

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Sophie Jacob, Quentin Voglimacci, Marie Odile Bernier, Juliette Thariat, Maryse Lapeyre-Mestre, et al.. Cardiac arrhythmias and conduction disorders after breast cancer treatment including radiotherapy: a study based on the French nationwide health database. Venice Arrhythmias 2019, Venice Arrhythmias, Oct 2019, VENISE, Italy. ⟨hal-03098809⟩
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