Distributed ledger technology, frequently designated as “blockchain,” is evolving from its hype phase toward greater maturity and long-term value creation. Although many academic communities were initially slow to grasp the technology’s numerous potential implications, meanwhile a substantial amount of research is dedicated to investigating the development and impact of blockchain and related technologies. As undertaken, most research projects take a specific homogenous perspective, such as a technical or business viewpoint. To date, blockchain research studies are largely missing a bridge between and across academic disciplines. Given the manifold implications of blockchain technology, a fruitful cross-disciplinary exchange is therefore needed. In this paper, we bring together researchers with varying expertise to provide a vision into what may be next in terms of concepts, applications, and research agendas. We consider business, economic, societal, legal, technical, and philosophical viewpoints and propose multiple research questions as well as hypotheses arising from these diverse viewpoints. Simultaneously, we challenge various academic communities to tackle some of the most crucial issues of current blockchain research and to develop a solid foundation for future exploration.