The aim of this paper is to provide the edition, with translation and commentary, of a short Syriac epistle by Severus Sebokht, bishop of Qenneshre (7th century), in which the author discusses some issues related to Aristotle’s Peri Hermeneias and Analytics. The commentary examines in detail Severus’ Syriac text by comparison with the Greek sources, namely the commentaries by Alexander of Aphrodisias, Ammonius, and Philoponus. In addition, in an appendix a study is included of a part of another epistle by Severus, concerning the existence of the possible, which shows a remarkable similarity with Alexander’s Question II 4.