Article Dans Une Revue Journal of Biological Chemistry Année : 2012

Deciphering the Role of CD1e Protein in Mycobacterial Phosphatidyl- myo -inositol Mannosides (PIM) Processing for Presentation by CD1b to T Lymphocytes

Résumé

Background: To become antigenic, mycobacterial hexamannosylated phosphatidyl-myo-inositol (PIM 6) undergo CD1eassisted ␣-mannosidase processing. Results: Measuring membrane-to-membrane PIM transfer, CD1e selectively transferred diacylated PIM species in accordance with the fact that liposome-inserted di-acylated PIM 6 were the only PIM species digested into antigenic molecules by ␣-mannosidase. Conclusion: CD1e assists PIM processing through its lipid transfer protein property. Significance: This study reveals the molecular mechanisms by which CD1e contributes to lipid immunoediting.

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hal-03096337 , version 1 (22-03-2021)

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Diane Cala-de Paepe, Emilie Layre, Gaëlle Giacometti, Luis Garcia-Alles, Lucia Mori, et al.. Deciphering the Role of CD1e Protein in Mycobacterial Phosphatidyl- myo -inositol Mannosides (PIM) Processing for Presentation by CD1b to T Lymphocytes. Journal of Biological Chemistry, 2012, 287 (37), pp.31494-31502. ⟨10.1074/jbc.M112.386300⟩. ⟨hal-03096337⟩
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