The Interdisciplinary Research Program “Organization and Well-Being” is aimed at identifying the relationships between the choices that structure the work processes, and the people’s health, defined in terms of physical, mental and social well-being. A method allowing to connect the analysis of organizational choices and the biomedical analysis of their consequences on the involved subjects has been the object of studies and discussions for three decades. This debate includes comments expressed from points of view concerning: ergonomics, work psychodynamics, work sociology, work psychology, ergology, linguistic activity. The way to conceive organization, action research, inter-disciplinarity and multi-disciplinarity, in the various approaches here represented, are the main object of discussion.