Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Molecular Psychiatry Année : 2020

Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments

Glenn Dallérac
Luca Pucci
  • Fonction : Auteur
Corrado Calì
  • Fonction : Auteur
Salvatore Lecca
  • Fonction : Auteur
Andrea Chicca
  • Fonction : Auteur
Andrei Ivanov
  • Fonction : Auteur
Cédric S Asensio
  • Fonction : Auteur
Vidar Gundersen
  • Fonction : Auteur
Nicolas Toni
Graham William Knott
  • Fonction : Auteur
Fulvio Magara
  • Fonction : Auteur
Jürg Gertsch
  • Fonction : Auteur
Frank Kirchhoff
  • Fonction : Auteur
Nicole Déglon
Bruno Giros
Robert H Edwards
  • Fonction : Auteur
Paola Bezzi
  • Fonction : Auteur
  • PersonId : 1086922

Résumé

Astrocytes orchestrate neural development by powerfully coordinating synapse formation and function and, as such, may be critically involved in the pathogenesis of neurodevelopmental abnormalities and cognitive deficits commonly observed in psychiatric disorders. Here, we report the identification of a subset of cortical astrocytes that are competent for regulating dopamine (DA) homeostasis during postnatal development of the prefrontal cortex (PFC), allowing for optimal DA-mediated maturation of excitatory circuits. Such control of DA homeostasis occurs through the coordinated activity of astroglial vesicular monoamine transporter 2 (VMAT2) together with organic cation transporter 3 and monoamine oxidase type B, two key proteins for DA uptake and metabolism. Conditional deletion of VMAT2 in astrocytes postnatally produces loss of PFC DA homeostasis, leading to defective synaptic transmission and plasticity as well as impaired executive functions. Our findings show a novel role for PFC astrocytes in the DA modulation of cognitive performances with relevance to psychiatric disorders.
Fichier principal
Vignette du fichier
Petrelli et al. Preprint.pdf (962.65 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03089133 , version 1 (27-12-2020)

Identifiants

Citer

Francesco Petrelli, Glenn Dallérac, Luca Pucci, Corrado Calì, Tamara Zehnder, et al.. Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments. Molecular Psychiatry, 2020, 25 (4), pp.732-749. ⟨10.1038/s41380-018-0226-y⟩. ⟨hal-03089133⟩
55 Consultations
45 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More