Absorption of plutonium compounds in the respiratory tract
Résumé
In order to optimise the monitoring of potentially exposed workers, it is desirable to determine specific values of absorption for the compounds handled. This study derives specific values of absorption rates for different chemical forms of plutonium from in vitro and animal (monkeys, dogs, mice, rats) experiments, and from human contamination cases. Different published experimental data have been reinterpreted here to derive values for the absorption parameters, fr, sr and ss, used in the human respiratory tract model currently adopted by the International Commission on Radiological Protection (ICRP). The consequences of the use of these values were investigated by calculating related committed effective doses per unit intake. Average and median estimates were calculated for fr, sr, and ss for each plutonium compound, that can be used as default values for specific chemical forms instead of the current reference types. Nevertheless, it was shown that the use of the current ICRP reference absorption types provides reasonable approximations. Moreover, this work provides estimates of the variability in pulmonary absorption and, therefore, facilitates analyses of the uncertainties associated with assessments, either from bioassay measurements or from prospective calculations, of intake and dose. © IOP Publishing Ltd.
Mots clés
Absorption rates
Chemical forms
Committed effective dose
Current reference
Default values
Experimental data
Human respiratory tract models
In-vitro
International commission on radiological protections
Per unit
Pulmonary absorption
Respiratory tract
Specific values
Bioassay
Plutonium
Plutonium compounds
Uncertainty analysis
Absorption
plutonium
absorption
air pollutant
animal
article
baboon
dog
exposure
human
Macaca
metabolism
Monte Carlo method
mouse
occupational exposure
radiation dose
radiation exposure
radiation protection
radiation response
radiometry
rat
reference value
respiratory system
risk assessment
Air Pollutants
Radioactive
Animals
Dogs
Dose-Response Relationship
Radiation
Humans
Inhalation Exposure
Macaca fascicularis
Mice
Monte Carlo Method
Occupational Exposure
Papio
Radiation Dosage
Radiation Protection
Radiometry
Rats
Reference Values
Respiratory System
Risk Assessment