Rhodium (III) Catalyzed Regioselective and Enantiospecific Allylic Arylation in Water by bêta-Fluorine Elimination of the Allylic Fluo-ride: toward the Synthesis of Z-alkenyl-unsaturated amides
Résumé
A direct coupling of arylboronic acids with allylic fluorides was carried out in water without additives using a rhodium(III) catalyst (Cp*RhCl2)2. The transformation proceeded with excellent γ-selectivity to afford major allyl–aryl coupling products (Z) γ-substituted α,β-unsaturated amides. The reactions of α-chiral allylic fluorides took place with excellent α-to-γ chirality transfer to give allylated arenes with a stereogenic center at the benzylic and allylic position.
Domaines
ChimieOrigine | Fichiers produits par l'(les) auteur(s) |
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