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Article Dans Une Revue Current Opinion in Structural Biology Année : 2020

AAA+ ATPases: structural insertions under the magnifying glass

Matthew Jessop
Irina Gutsche

Résumé

AAA+ ATPases are a diverse protein superfamily which power a vast number of cellular processes, from protein degradation to genome replication and ribosome biogenesis. The latest advances in cryo-EM have resulted in a spectacular increase in the number and quality of AAA+ ATPase structures. This abundance of new information enables closer examination of different types of structural insertions into the conserved core, revealing discrepancies in the current classification of AAA+ modules into clades. Additionally, combined with biochemical data, it has allowed rapid progress in our understanding of structure-functional relationships and provided arguments both in favour and against the existence of a unifying molecular mechanism for the ATPase activity and action on substrates, stimulating further intensive research.
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Dates et versions

hal-03071111 , version 1 (16-12-2020)

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Matthew Jessop, Jan Felix, Irina Gutsche. AAA+ ATPases: structural insertions under the magnifying glass. Current Opinion in Structural Biology, 2020, 66, pp.119-128. ⟨10.1016/j.sbi.2020.10.027⟩. ⟨hal-03071111⟩
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