Cobalt is economically considered as a critical metal. The main known Co ore deposits are found in the Katanga Copperbelt (Democratic Republic of Congo) where a high richness of Cu-Co tolerant and accumulator plants have developed. Cobalt mining has disseminated and disseminates large quantities of wastes in the environment and becomes a major environmental issue. Reduction of environmental risks and Co dispersion can be performed by phytoremediation and/or agromining, using trace element tolerant and putative hyperaccumulator plants originated from the biodiversity of natural Co/Cu-enriched habitats. Accumulation of foliar Co to >300 μg g-1 is exceptionally rare globally, and known principally from the Copperbelt of Central Africa. This chapter highlights advances on Co accumulation in plants, examines the potential of a Co accumulator in agromining, and defines perspectives for Co agromining by designing multi-functions and services of agroecosystems by a functional plant traits approach.