Microtubule self-repair - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Current Opinion in Cell Biology Année : 2021

Microtubule self-repair

Microtubule self-repair.

Résumé

The stochastic switching between microtubule growth and shrinkage is a fascinating and unique process in the regulation of the cytoskeleton. To understand it, almost all attention has been focused on the microtubule ends. However, recent research has revived the idea that tubulin dimers can also be exchanged in protofilaments along the microtubule shaft, thus repairing the microtubule and protecting it from disassembly. Here, we review the research describing this phenomenon, the mechanisms regulating the removal and insertion of tubulin dimers, as well as the potential implications for key functions of the microtubule network, such as intracellular transport and cell polarization.
Fichier principal
Vignette du fichier
S0955067420301472.pdf (1.55 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03066268 , version 1 (21-11-2022)

Licence

Paternité - Pas de modifications

Identifiants

Citer

Manuel Théry, Laurent Blanchoin. Microtubule self-repair. Current Opinion in Cell Biology, 2021, 68, pp.144-154. ⟨10.1016/j.ceb.2020.10.012⟩. ⟨hal-03066268⟩
63 Consultations
82 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More