Drawing on Self-Determination Theory, this study explored the motivational profiles toward Physical Activity (PA) among adults with type 2 diabetes and the relationships between motivational profile, perceived competence and PA. Participants were 350 men and women (Mean age 62.77 years) who were interviewed on their motivations toward PA, perceived level of competence to practice, and PA practice. Cluster analyses reveal the existence of three distinct profiles: “High Combined” (ie, high scores on motivations ranging from intrinsic to external regulation, moderate level on amotivation), “Self-Determined” (ie, high scores on intrinsic, integrated, and identified regulations; low scores on other regulations), and “Moderate” (ie, moderate scores on all regulations). Participants with “High Combined” and “Self-Determined” profiles reported higher perceived competence and longer leisure-time PA practice in comparison to those with a “Moderate” profile. This study highlights the necessity of adopting a person-centered approach to better understand motivation toward PA among type 2 diabetics.