In the present review, we discuss the results of the research we have done over the last decade on multiporphyrinic architectures bearing a nucleotidic backbone, compare all the data, offer a novel overview, and emphasize common capabilities of nucleosides appearing in various systems, providing a new insight on the preorganizing capabilities of nucleosidic backbones. The efficiency of nucleosides as preorganizing agents was investigated through the synthesis and study of various bisporphyrins bearing nucleosidic linkers, as well as through the investigation of the conformation of linear and arborescent multiporphyrins constructed on a nucleosidic backbone. The capacity of these molecules to complex guests with a high association constant was used as a tool to evaluate their degree of preorganization, as well as the investigation of the electronic coupling existing between their chromophores and their photo chemical capacities. Such an overview of one decade of scientific investigations documents the fact that rigid linkers between chromophores are not necessary for their spatial preorganization, opening new routes to the faster synthesis of flexible highly preorganized molecular architectures avoiding the long and tedious synthesis of rigid tweezers, especially for the preparation of rigid linkers which may bring solubility and stability problems.