<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03052753v1</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-15T03:13:21+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Physical modeling of a sliding clamp mechanism for the spreading of ParB at short genomic distance from bacterial centromere sites</title>
            <author role="crp">
              <persName>
                <forename type="first">Jean-Charles</forename>
                <surname>Walter</surname>
              </persName>
              <email type="md5">0ad6278c6415a2ee6062304ba85e34f8</email>
              <email type="domain">umontpellier.fr</email>
              <idno type="idhal" notation="string">jean-charles-walter</idno>
              <idno type="idhal" notation="numeric">738456</idno>
              <idno type="halauthorid" notation="string">34635-738456</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7313-0100</idno>
              <idno type="IDREF">https://www.idref.fr/139250964</idno>
              <affiliation ref="#struct-136223"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jerome</forename>
                <surname>Rech</surname>
              </persName>
              <email type="md5">80023fd0fa8867e47507bbce1220a4ee</email>
              <email type="domain">ibcg.biotoul.fr</email>
              <idno type="idhal" notation="string">jerome-rech-fr</idno>
              <idno type="idhal" notation="numeric">184674</idno>
              <idno type="halauthorid" notation="string">47486-184674</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=DbOdcUgAAAAJ&amp;hl=fr</idno>
              <affiliation ref="#struct-552481"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nils-Ole</forename>
                <surname>Walliser</surname>
              </persName>
              <email type="md5">61b20aa40df8156f3112102f214ff1e6</email>
              <email type="domain">umontpellier.fr</email>
              <idno type="idhal" notation="string">nils-ole-walliser</idno>
              <idno type="idhal" notation="numeric">1299268</idno>
              <idno type="halauthorid" notation="string">1280274-1299268</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3232-1872</idno>
              <affiliation ref="#struct-136223"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jerome</forename>
                <surname>Dorignac</surname>
              </persName>
              <email type="md5">0abe1b8f8e57629e73753220bba2a61d</email>
              <email type="domain">umontpellier.fr</email>
              <idno type="idhal" notation="string">jerome-dorignac</idno>
              <idno type="idhal" notation="numeric">1509923</idno>
              <idno type="halauthorid" notation="string">389702-1509923</idno>
              <idno type="ORCID">https://orcid.org/0009-0005-0107-2350</idno>
              <idno type="IDREF">https://www.idref.fr/250157705</idno>
              <idno type="VIAF">https://viaf.org/viaf/62160789858802682279</idno>
              <affiliation ref="#struct-136223"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Frederic</forename>
                <surname>Geniet</surname>
              </persName>
              <email type="md5">10d2e637fc2295556d83820001909930</email>
              <email type="domain">lpm.univ-montp2.fr</email>
              <idno type="idhal" notation="string">frederic-geniet</idno>
              <idno type="idhal" notation="numeric">1004445</idno>
              <idno type="halauthorid" notation="string">1151160-1004445</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9133-9151</idno>
              <idno type="IDREF">https://www.idref.fr/033777217</idno>
              <idno type="VIAF">https://viaf.org/viaf/226402983</idno>
              <idno type="ISNI">http://isni.org/isni/0000000363349288</idno>
              <affiliation ref="#struct-136223"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">John</forename>
                <surname>Palmeri</surname>
              </persName>
              <email type="md5">d33b140e52de9a2429d8507bb43d20d1</email>
              <email type="domain">umontpellier.fr</email>
              <idno type="idhal" notation="string">john-palmeri</idno>
              <idno type="idhal" notation="numeric">737338</idno>
              <idno type="halauthorid" notation="string">34636-737338</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-6337-0955</idno>
              <idno type="IDREF">https://www.idref.fr/06872876X</idno>
              <affiliation ref="#struct-136223"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Andrea</forename>
                <surname>Parmeggiani</surname>
              </persName>
              <email type="md5">aa05600540e48d938f5aa0b76912bdc7</email>
              <email type="domain">univ-montp2.fr</email>
              <idno type="idhal" notation="string">andrea-parmeggiani</idno>
              <idno type="idhal" notation="numeric">758050</idno>
              <idno type="halauthorid" notation="string">208880-758050</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-3025-4266</idno>
              <idno type="IDREF">https://www.idref.fr/03490171X</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=dHA2JQUAAAAJ</idno>
              <idno type="VIAF">https://viaf.org/viaf/41956677</idno>
              <idno type="ISNI">http://isni.org/isni/0000000031184632</idno>
              <affiliation ref="#struct-136223"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Jean-Yves</forename>
                <surname>Bouet</surname>
              </persName>
              <email type="md5">59898009ed5a6771dd0ff4f368525ab2</email>
              <email type="domain">univ-tlse3.fr</email>
              <idno type="idhal" notation="string">jybouet</idno>
              <idno type="idhal" notation="numeric">1086415</idno>
              <idno type="halauthorid" notation="string">26695-1086415</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1488-5455</idno>
              <idno type="IDREF">https://www.idref.fr/142527009</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=KzzIy8oAAAAJ</idno>
              <affiliation ref="#struct-552481"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>L2c</forename>
                <surname>Aigle</surname>
              </persName>
              <email type="md5">896b4172ec7889f15eabdfaa746b8133</email>
              <email type="domain">umontpellier.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2020-11-05 15:50:03</date>
              <date type="whenWritten">2020-07-24</date>
              <date type="whenModified">2025-10-22 18:04:08</date>
              <date type="whenReleased">2020-11-06 10:04:48</date>
              <date type="whenProduced">2020-07-24</date>
              <date type="whenEndEmbargoed">2020-11-05</date>
              <ref type="file" target="https://hal.science/hal-03052753v1/document">
                <date notBefore="2020-11-05"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-03052753v1/file/2020.07.22.213413.full.pdf" id="file-2990554-2633859">
                <date notBefore="2020-11-05"/>
              </ref>
            </edition>
            <edition n="v2">
              <date type="whenSubmitted">2020-12-10 17:24:09</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="157154">
                <persName>
                  <forename>L2c</forename>
                  <surname>Aigle</surname>
                </persName>
                <email type="md5">896b4172ec7889f15eabdfaa746b8133</email>
                <email type="domain">umontpellier.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03052753</idno>
            <idno type="halUri">https://hal.science/hal-03052753</idno>
            <idno type="halBibtex">walter:hal-03052753</idno>
            <idno type="halRefHtml">2020</idno>
            <idno type="halRef">2020</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-2990554-2633859"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt/>
          <notesStmt/>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Physical modeling of a sliding clamp mechanism for the spreading of ParB at short genomic distance from bacterial centromere sites</title>
                <author role="crp">
                  <persName>
                    <forename type="first">Jean-Charles</forename>
                    <surname>Walter</surname>
                  </persName>
                  <email type="md5">0ad6278c6415a2ee6062304ba85e34f8</email>
                  <email type="domain">umontpellier.fr</email>
                  <idno type="idhal" notation="string">jean-charles-walter</idno>
                  <idno type="idhal" notation="numeric">738456</idno>
                  <idno type="halauthorid" notation="string">34635-738456</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7313-0100</idno>
                  <idno type="IDREF">https://www.idref.fr/139250964</idno>
                  <affiliation ref="#struct-136223"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jerome</forename>
                    <surname>Rech</surname>
                  </persName>
                  <email type="md5">80023fd0fa8867e47507bbce1220a4ee</email>
                  <email type="domain">ibcg.biotoul.fr</email>
                  <idno type="idhal" notation="string">jerome-rech-fr</idno>
                  <idno type="idhal" notation="numeric">184674</idno>
                  <idno type="halauthorid" notation="string">47486-184674</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=DbOdcUgAAAAJ&amp;hl=fr</idno>
                  <affiliation ref="#struct-552481"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nils-Ole</forename>
                    <surname>Walliser</surname>
                  </persName>
                  <email type="md5">61b20aa40df8156f3112102f214ff1e6</email>
                  <email type="domain">umontpellier.fr</email>
                  <idno type="idhal" notation="string">nils-ole-walliser</idno>
                  <idno type="idhal" notation="numeric">1299268</idno>
                  <idno type="halauthorid" notation="string">1280274-1299268</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3232-1872</idno>
                  <affiliation ref="#struct-136223"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jerome</forename>
                    <surname>Dorignac</surname>
                  </persName>
                  <email type="md5">0abe1b8f8e57629e73753220bba2a61d</email>
                  <email type="domain">umontpellier.fr</email>
                  <idno type="idhal" notation="string">jerome-dorignac</idno>
                  <idno type="idhal" notation="numeric">1509923</idno>
                  <idno type="halauthorid" notation="string">389702-1509923</idno>
                  <idno type="ORCID">https://orcid.org/0009-0005-0107-2350</idno>
                  <idno type="IDREF">https://www.idref.fr/250157705</idno>
                  <idno type="VIAF">https://viaf.org/viaf/62160789858802682279</idno>
                  <affiliation ref="#struct-136223"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Frederic</forename>
                    <surname>Geniet</surname>
                  </persName>
                  <email type="md5">10d2e637fc2295556d83820001909930</email>
                  <email type="domain">lpm.univ-montp2.fr</email>
                  <idno type="idhal" notation="string">frederic-geniet</idno>
                  <idno type="idhal" notation="numeric">1004445</idno>
                  <idno type="halauthorid" notation="string">1151160-1004445</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9133-9151</idno>
                  <idno type="IDREF">https://www.idref.fr/033777217</idno>
                  <idno type="VIAF">https://viaf.org/viaf/226402983</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000363349288</idno>
                  <affiliation ref="#struct-136223"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">John</forename>
                    <surname>Palmeri</surname>
                  </persName>
                  <email type="md5">d33b140e52de9a2429d8507bb43d20d1</email>
                  <email type="domain">umontpellier.fr</email>
                  <idno type="idhal" notation="string">john-palmeri</idno>
                  <idno type="idhal" notation="numeric">737338</idno>
                  <idno type="halauthorid" notation="string">34636-737338</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-6337-0955</idno>
                  <idno type="IDREF">https://www.idref.fr/06872876X</idno>
                  <affiliation ref="#struct-136223"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Andrea</forename>
                    <surname>Parmeggiani</surname>
                  </persName>
                  <email type="md5">aa05600540e48d938f5aa0b76912bdc7</email>
                  <email type="domain">univ-montp2.fr</email>
                  <idno type="idhal" notation="string">andrea-parmeggiani</idno>
                  <idno type="idhal" notation="numeric">758050</idno>
                  <idno type="halauthorid" notation="string">208880-758050</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-3025-4266</idno>
                  <idno type="IDREF">https://www.idref.fr/03490171X</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=dHA2JQUAAAAJ</idno>
                  <idno type="VIAF">https://viaf.org/viaf/41956677</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000031184632</idno>
                  <affiliation ref="#struct-136223"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Jean-Yves</forename>
                    <surname>Bouet</surname>
                  </persName>
                  <email type="md5">59898009ed5a6771dd0ff4f368525ab2</email>
                  <email type="domain">univ-tlse3.fr</email>
                  <idno type="idhal" notation="string">jybouet</idno>
                  <idno type="idhal" notation="numeric">1086415</idno>
                  <idno type="halauthorid" notation="string">26695-1086415</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1488-5455</idno>
                  <idno type="IDREF">https://www.idref.fr/142527009</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=KzzIy8oAAAAJ</idno>
                  <affiliation ref="#struct-552481"/>
                </author>
              </analytic>
              <monogr>
                <idno type="localRef">L2C:20-105</idno>
                <imprint/>
              </monogr>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="phys.phys.phys-bio-ph">Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph]</classCode>
              <classCode scheme="halTypology" n="UNDEFINED">Preprints, Working Papers, ...</classCode>
              <classCode scheme="halOldTypology" n="UNDEFINED">Preprints, Working Papers, ...</classCode>
              <classCode scheme="halTreeTypology" n="UNDEFINED">Preprints, Working Papers, ...</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Bacterial ParB partitioning proteins involved in chromosomes and low-copy-number plasmid segregation have recently been shown to belong to a new class of CTP-dependent molecular switches. Strikingly, CTP binding and hydrolysis was shown to induce a conformational change enabling ParB dimers to switch between an open and a closed conformation. This latter conformation clamps ParB dimers on DNA molecules, allowing their diffusion in one dimension along the DNA. It has been proposed that this novel sliding property may explain the spreading capability of ParB over more than 10-Kb from parS centromere sites where ParB is specifically loaded. Here, we modeled such a mechanism as a typical reaction-diffusion system and compared this ‘Clamping &amp; sliding’ model to the ParB DNA binding pattern from high-resolution ChIP-sequencing data. We found that this mechanism can not account for all the in vivo characteristics, especially the long range of ParB binding to DNA. In particular, it predicts a strong effect of the presence of a roadblock on the ParB binding pattern that is not observed in ChIP-seq. Moreover, the rapid assembly kinetics observed in vivo after the duplication of parS sites is not easily explained by this mechanism. We propose that ‘Clamping &amp; sliding’ might explain the ParB spreading pattern at short distances from parS but that another mechanism must apply for ParB recruitment at larger genomic distances.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-136223" status="OLD">
          <idno type="ISNI">0000000446872402</idno>
          <idno type="RNSR">201119402W</idno>
          <idno type="ROR">https://ror.org/02ftce284</idno>
          <orgName>Laboratoire Charles Coulomb</orgName>
          <orgName type="acronym">L2C</orgName>
          <date type="start">2011-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1 place Eugène Bataillon Université Montpellier 34095 Montpellier Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://coulomb.umontpellier.fr</ref>
          </desc>
          <listRelation>
            <relation name="HR10M00506" active="#struct-410122" type="direct"/>
            <relation name="UMR5221" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-552481" status="OLD">
          <idno type="RNSR">201622188C</idno>
          <orgName>Centre de Biologie Intégrative</orgName>
          <orgName type="acronym">CBI</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>Université Paul Sabatier,18 Route de Narbonne, 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://cbi-toulouse.fr/fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-217752" type="direct"/>
            <relation active="#struct-443875" type="indirect"/>
            <relation name="FR3743" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-410122" status="OLD">
          <idno type="ISNI">0000000120970141</idno>
          <idno type="ROR">https://ror.org/051escj72</idno>
          <orgName>Université de Montpellier</orgName>
          <orgName type="acronym">UM</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.umontpellier.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-217752" status="OLD">
          <idno type="IdRef">026404672</idno>
          <idno type="ISNI">0000000121617331</idno>
          <idno type="ROR">https://ror.org/02v6kpv12</idno>
          <idno type="Wikidata">Q1273188</idno>
          <orgName>Université Toulouse III - Paul Sabatier</orgName>
          <orgName type="acronym">UT3</orgName>
          <date type="end">2025-01-01</date>
          <desc>
            <address>
              <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tlse3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-443875" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-443875" status="VALID">
          <idno type="ROR">https://ror.org/017tgbk05</idno>
          <orgName>Communauté d'universités et établissements de Toulouse</orgName>
          <orgName type="acronym">Comue de Toulouse</orgName>
          <desc>
            <address>
              <addrLine>41 Allée Jules Guesde, 31000 Toulouse</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.univ-toulouse.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>