Clopidogrel-related platelet inhibition: correlation with perioperative adverse events in neurointerventional procedures - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue The eJournal of the European Society of Minimally Invasive Neurological Therapy Année : 2014

Clopidogrel-related platelet inhibition: correlation with perioperative adverse events in neurointerventional procedures

Igor Lima Maldonado
Catherine Seris
  • Fonction : Auteur
Ricardo Mernes
  • Fonction : Auteur
Kyriakos Lobotesis
  • Fonction : Auteur
Sandra Rodrigues
  • Fonction : Auteur
Vincent Costalat
  • Fonction : Auteur
  • PersonId : 1056305
Paolo Machi
  • Fonction : Auteur
  • PersonId : 980644
Jean Francois Vendrell
  • Fonction : Auteur
Alain Bonafe
  • Fonction : Auteur
  • PersonId : 1036223

Résumé

Introduction and Purpose: The measurement of the level of platelet inhibition may be useful in quantifying the risk of thromboembolic complication in subjects undergoing endovascular treatment using implantable materials. We studied the predictability of the VerifyNow point-of-care assay in a large sample of consecutive neurointerventional procedures. Methods: The percentage of P2Y12-inhibition was systematically measured in a total of 271 procedures (245 patients). The incidences of poor response and adverse events within the first 48 hours were recorded . Results: The overall occurrence of poor response after a single loading-dose of 300 mg was 61.3% using a cut-off of 40% and 43.9% using a cut-off of 20%. In the analysis of the incidence of adverse events by P2Y12-inhibition grouping, a significant association was observed between thromboembolic events and low response, with an overall incidence of 10.2% (cut-off of 40%) and 11.8% (cut-off of 20%). The assessment of predictability using different cut-offs showed that more than 90% of thromboembolic events would be in the group of poor responders using a 40% cut-off and more than 75% using 20%. Conclusion: The use of the VerifyNow assay in the neurointerventional context seems a valuable tool in the early detection of individuals at risk of perioperative thromboembolic adverse events.
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Dates et versions

hal-03052507 , version 1 (10-12-2020)

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  • HAL Id : hal-03052507 , version 1

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Igor Lima Maldonado, Catherine Seris, Ricardo Mernes, Kyriakos Lobotesis, Sandra Rodrigues, et al.. Clopidogrel-related platelet inhibition: correlation with perioperative adverse events in neurointerventional procedures. The eJournal of the European Society of Minimally Invasive Neurological Therapy, 2014. ⟨hal-03052507⟩
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