Acute syndrome of radiation: Injuries to the gastrointestinal tract - Archive ouverte HAL
Article Dans Une Revue Radioprotection Année : 2002

Acute syndrome of radiation: Injuries to the gastrointestinal tract

Syndrome aigu d'irradiation: les atteintes du système gastro-intestinal

Résumé

Exposure to ionising radiation at medium to high doses results in the manifestation of mixed pathologies. Following the analysis of several radiation accidents it is clear that intestinal injury influences patient survival. However the appearance of the classically defined gastrointestinal syndrome is not always evident. Nevertheless injury to the gastrointestinal tract, in particular loss of barrier function, seems to play an important role in the development of Multiple Organ Failure such as reported in the recent accident at Tokai Mura. Ionising radiation overexposure results in changes in intestinal motility and nutrient, fluid and electrolyte absorption and secretion all which may contribute to the genesis of diarrhoea. In addition to modified cellular transport properties for nutrients or electrolytes, important loss of epithelial cells is also a major contributing factor. Intestinal functions are controlled by many factors such as neurotransmitters, locally released mediators from endocrine cells or immunocompetent cells in addition to luminal agents. To date, treatment of radiation-induced gastrointestinal injury is mainly symptomatic. However treatments such as growth factors, anti-inflammatory cytokines as well as cellular transplantation remain to be validated in the radiation accident situation. © 2002 EDP Sciences.

Dates et versions

hal-03051726 , version 1 (10-12-2020)

Identifiants

Citer

N.M. Griffiths, I. Dublineau, F. Lebrun, C. Linard, P. Monti, et al.. Acute syndrome of radiation: Injuries to the gastrointestinal tract. Radioprotection, 2002, 37 (2), pp.161-171. ⟨10.1051/radiopro:2002006⟩. ⟨hal-03051726⟩

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