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Article Dans Une Revue EJSO - European Journal of Surgical Oncology Année : 2021

Mucoepidermoid carcinoma of salivary glands: A French Network of Rare Head and Neck Tumors (REFCOR) prospective study of 292 cases

1 LA CONCEPTION - Hôpital de la Conception [CHU - APHM]
2 AMU - Aix Marseille Université
3 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
4 TIMONE - Hôpital de la Timone [CHU - APHM]
5 BiosTIC - Biostatistique et technologies de l'information et de la communication (BioSTIC) - [Hôpital de la Timone - APHM]
6 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
7 CHU Bordeaux
8 CHU Montpellier
9 Hôpital Lariboisière-Fernand-Widal [APHP]
10 UNICANCER/CAL - Centre de Lutte contre le Cancer Antoine Lacassagne [Nice]
11 Institut Universitaire de la Face et du Cou [Nice]
12 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
13 CHU Nantes - Centre Hospitalier Universitaire de Nantes
14 IUCT Oncopole - UMR 1037 - Institut Universitaire du Cancer de Toulouse - Oncopole
15 AP-HP - Hôpital Bichat - Claude Bernard [Paris]
16 Hôpital Foch [Suresnes]
17 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
18 Hôpital universitaire Robert Debré [Reims]
19 UNICANCER/CRLC - Centre Régional de Lutte contre le Cancer François Baclesse [Caen]
20 CHU Clermont-Ferrand
21 CHU de Poitiers - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
22 CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]
23 IGR - Institut Gustave Roussy
24 CCF - Département de cancérologie cervico-faciale [Gustave Roussy]
25 CHU Tenon [AP-HP]
26 SU - Sorbonne Université
Renaud Garrel
  • Fonction : Auteur

Résumé

Background: To describe the characteristics of the largest European study of MEC of salivary glands and to determine the prognostic factors for overall and disease free survival.Patients and methods: Patients with MEC were prospectively included in the Réseau d'Expertise Français sur les Cancers ORL Rares (REFCOR, French Network of Rare Head and Neck Tumors) database between 2009 and 2015.Results: A total of 292 patients were included. Tumors were classified as low grade in 175 cases (60%), intermediate in 39 (13%) and high grade in 78 (27%). Median follow-up was 26 months. The 5-year OS and DFS rates were respectively 83% and 69%. In multivariate analysis, age (p = 0.004), diabetes (p = 0.02) and advanced stage (p = 0.03) were found to have a significant negative impact on OS. Diabetes (p = 0.001), alcohol consumption (p = 0.003) and advanced stage (p = 0.001) were found to have a significant negative impact on DFS. Compare to low grade, high grade tended to have a negative impact on OS (p = 0.05) and had a significant effect on DFS (0.002) while intermediate grade had no significant influence on survival. The surgical treatment had a positive impact on both OS (p = 0.00005) and DFS (p = 0.0005). Postoperative radiotherapy had no impact in multivariate analysis.Conclusion: Advanced clinical stage, high grade tumor, high age, the impossibility of carrying out a complete surgical resection, and diabetes are the main prognostic factors in this prospective series of patients with MEC. Such findings open new research perspectives on the influence of these components on initial patient care.
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Dates et versions

hal-03049061 , version 1 (24-05-2023)

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Paternité - Pas d'utilisation commerciale

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Citer

Laurie Saloner Dahan, Roch Giorgi, Sébastien Vergez, Ludovic Le Taillandier de Gabory, Valérie Costes-Martineau, et al.. Mucoepidermoid carcinoma of salivary glands: A French Network of Rare Head and Neck Tumors (REFCOR) prospective study of 292 cases. EJSO - European Journal of Surgical Oncology, 2021, 47 (6), pp.1376-1383. ⟨10.1016/j.ejso.2020.11.123⟩. ⟨hal-03049061⟩
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