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Article Dans Une Revue Evolutionary Applications Année : 2019

The functional convergence of antibiotic resistance in β‐lactamases is not conferred by a simple convergent substitution of amino acid

Résumé

Antibiotics are medicines that fight bacterial infection, but there is a growing problem of antibiotic resistance when bacteria become able to resist the effects of antibiotics. Antibiotic-resistant genes spread in the environment quickly due to overuse of antibiotics which imposes a strong selection pressure favoring resistance. For instance, humans use a range of antibiotics in agriculture and fish farming, as standard prophylactic measures, which leads to the widespread evolution of antibiotic-resistant genes (Economou & Gousia, 2015). A common enzymatic resistance
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hal-03047294 , version 1 (08-12-2020)

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Vivek Keshri, Kevin Arbuckle, Olivier Chabrol, Jean‐marc Rolain, Didier Raoult, et al.. The functional convergence of antibiotic resistance in β‐lactamases is not conferred by a simple convergent substitution of amino acid. Evolutionary Applications, 2019, 12 (9), pp.1812-1822. ⟨10.1111/eva.12835⟩. ⟨hal-03047294⟩
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