Host-Derived Lipids from Tuberculous Pleurisy Impair Macrophage Microbicidal-Associated Metabolic Activity
Résumé
Highlights d Tuberculous pleural effusion (TB-PE) shifts glycolysis to OXPHOS in M1 macrophages d Metabolic shift is accompanied by low HIF-1a activity and high M. tuberculosis burden d HIF-1a stabilization reverts the metabolic shift and inhibitory effects of TB-PE d Host-derived lipids (eicosanoid-enriched fraction) in TB-PE drive the metabolic shift
Domaines
Sciences du Vivant [q-bio]
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