Article Dans Une Revue European Journal of Organic Chemistry Année : 2019

Solvent-Free N-Alkylation of Amides with Alcohols Catalyzed by Nickel on Silica-Alumina

Résumé

The N-alkylation of phenylacetamide with benzyl alcohol has been studied using Ni/SiO2-Al2O3. In the optimized conditions, the desired product was isolated in an excellent 98% yield. The reaction could advantageously be performed in neat conditions, with a slight excess of amide and a catalytic amount of base. These conditions were tested on a large range of amides and alcohols, affording 24 compounds in 13 to 99% isolated yields.

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hal-03041065 , version 1 (04-12-2020)

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Aubin Charvieux, Louis Le Moigne, Lorenzo G Borrego, Nicolas Duguet, Estelle Metay. Solvent-Free N-Alkylation of Amides with Alcohols Catalyzed by Nickel on Silica-Alumina. European Journal of Organic Chemistry, 2019, 2019 (40), pp.6842-6846. ⟨10.1002/ejoc.201901291⟩. ⟨hal-03041065⟩
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