Interaction of smoking and radon in rats: A biologically based mechanistic model
Résumé
Data on rats exposed to cigarette smoke before or after exposure to radon are used to estimate smoke-dependent parameters of the biologically based two-stage clonal expansion model. The baseline parameters and the action of radon acting on initiation and promotion were fixed based on earlier work. Cigarette smoke acting on transformation and inducing a reduction of the radon dose to the target cells after a smoking period gives an acceptable description of the data. © Springer-Verlag 2005.
Mots clés
Cloning
Dosimetry
Targets
Clonal expansion models
Radon dose
Target cells
Radon
cigarette smoke
radon
animal experiment
animal model
article
cell interaction
nonhuman
radiation exposure
rat
smoking
target cell
Animals
Biophysics
Cocarcinogenesis
Dose-Response Relationship
Radiation
Humans
Lung Neoplasms
Models
Biological
Neoplasms
Radiation-Induced
Rats
Smoking
Time Factors
Animalia