Nanoparticle detection by solid state nanopore integrated into a reusable microfluidic device
Résumé
Solid-state nanopores can be used as electrical biosensors at the single molecule resolution. Such high resolution sensors provide a promising approach to address societal challenges in health and biotechnology. Nevertheless, the analytes detection is still limited by non-specific interactions between these molecules and the membrane supporting the nanopore. Therefore, we performed a polymer functionalization of the nanopore surface that allows to passivate the membrane and to control the pore size. Moreover, we integrated the solid-state nanopore in a reusable microfluidic device, thereby reducing the sample volume needed to perform the detection. The combination of these two approaches is applied to the sensing of single thyroglobulin protein.
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