<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03028090</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-24T21:13:23+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Capacity of an in vitro rat skin model to predict human dermal absorption: influences of aging and anatomical site</title>
            <title xml:lang="fr">Capacité d’un modèle de rat ex vivo à prédire l’absorption dermique chez l’homme : influence de l’âge et du site anatomique</title>
            <author role="aut">
              <persName>
                <forename type="first">Fabrice</forename>
                <surname>Marquet</surname>
              </persName>
              <email type="md5">84d9e1c45a035b9a658c7faf6ab77e46</email>
              <email type="domain">inrs.fr</email>
              <idno type="idhal" notation="numeric">1083253</idno>
              <idno type="halauthorid" notation="string">214577-1083253</idno>
              <affiliation ref="#struct-159664"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie-Christine</forename>
                <surname>Grandclaude</surname>
              </persName>
              <idno type="halauthorid">2063838-0</idno>
              <affiliation ref="#struct-159664"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Elisabeth</forename>
                <surname>Ferrari</surname>
              </persName>
              <idno type="halauthorid">2063837-0</idno>
              <affiliation ref="#struct-159664"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Catherine</forename>
                <surname>Champmartin</surname>
              </persName>
              <idno type="halauthorid">806934-0</idno>
              <affiliation ref="#struct-159664"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Chantal</forename>
                <surname>ROLIN</surname>
              </persName>
              <email type="md5">7c94028621c91712f44a1aa6195b6c5d</email>
              <email type="domain">inrs.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2020-11-27 14:10:11</date>
              <date type="whenWritten">2019-03-04</date>
              <date type="whenModified">2024-04-15 13:06:31</date>
              <date type="whenReleased">2020-12-01 14:29:29</date>
              <date type="whenProduced">2019-08-07</date>
              <date type="whenEndEmbargoed">2021-08-08</date>
              <ref type="file" target="https://hal.science/hal-03028090v1/document">
                <date notBefore="2021-08-08"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-03028090v1/file/Capacity%20of%20an%20in%20vitro%20rat%20skin%20model%20to%20predict%20human%20dermal%20absorption%20TIV.pdf" id="file-3028090-2671551">
                <date notBefore="2021-08-08"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="937216">
                <persName>
                  <forename>Chantal</forename>
                  <surname>ROLIN</surname>
                </persName>
                <email type="md5">7c94028621c91712f44a1aa6195b6c5d</email>
                <email type="domain">inrs.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03028090</idno>
            <idno type="halUri">https://hal.science/hal-03028090</idno>
            <idno type="halBibtex">marquet:hal-03028090</idno>
            <idno type="halRefHtml">&lt;i&gt;Toxicology in Vitro&lt;/i&gt;, 2019, &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.tiv.2019.104623"&gt;&amp;#x27E8;10.1016/j.tiv.2019.104623&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Toxicology in Vitro, 2019, &amp;#x27E8;10.1016/j.tiv.2019.104623&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3028090-2671551"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INRS">Institut National de Recherche et de Sécurité</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Capacity of an in vitro rat skin model to predict human dermal absorption: influences of aging and anatomical site</title>
                <title xml:lang="fr">Capacité d’un modèle de rat ex vivo à prédire l’absorption dermique chez l’homme : influence de l’âge et du site anatomique</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Fabrice</forename>
                    <surname>Marquet</surname>
                  </persName>
                  <email type="md5">84d9e1c45a035b9a658c7faf6ab77e46</email>
                  <email type="domain">inrs.fr</email>
                  <idno type="idhal" notation="numeric">1083253</idno>
                  <idno type="halauthorid" notation="string">214577-1083253</idno>
                  <affiliation ref="#struct-159664"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie-Christine</forename>
                    <surname>Grandclaude</surname>
                  </persName>
                  <idno type="halauthorid">2063838-0</idno>
                  <affiliation ref="#struct-159664"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Elisabeth</forename>
                    <surname>Ferrari</surname>
                  </persName>
                  <idno type="halauthorid">2063837-0</idno>
                  <affiliation ref="#struct-159664"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Catherine</forename>
                    <surname>Champmartin</surname>
                  </persName>
                  <idno type="halauthorid">806934-0</idno>
                  <affiliation ref="#struct-159664"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">19666</idno>
                <idno type="issn">0887-2333</idno>
                <idno type="eissn">1879-3177</idno>
                <title level="j">Toxicology in Vitro</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <date type="datePub">2019-08-07</date>
                  <date type="dateEpub">2019-08-08</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.tiv.2019.104623</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">transdermal chemical delivery</term>
                <term xml:lang="en">in vitro skin permeation</term>
                <term xml:lang="en">human</term>
                <term xml:lang="en">rat</term>
                <term xml:lang="en">Species specificity</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.tox">Life Sciences [q-bio]/Toxicology</classCode>
              <classCode scheme="halDomain" n="sdv.bdlr">Life Sciences [q-bio]/Reproductive Biology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>In addition to inhalation, dermal absorption is a route of exposure to be considered when assessing occupational risks. To investigate dermal penetration of chemicals, human skin samples are regarded as the gold standard. As human samples can be difficult to obtain, many experiments are performed with rat skins, and the results extrapolated to describe human percutaneous absorption. Here, we examined the characteristics of rat skin samples and compared absorption to that measured with in vitro human skin. The thickness of the stratum corneum layer in rat skin samples was found to be uniform when samples were excised from the animals' backs once they were at least 7-weeks-old. Overall, dorsal skin samples from mature rats could be reliably used to measure the flux of hydrophilic liquid molecules, such as N-methyl-2-pyrrolidone, and N,N-dimethylformamide. In contrast, with a solid lipophilic substance, bisphenol A, dissolved in acetone, the flux obtained with rat skin samples was 3-2 fold higher than that measured with human skin. Consequently, it does not appear relevant to use rat skin in place of human skin to measure absorption of solid lipophilic substances.</p>
            </abstract>
            <abstract xml:lang="fr">
              <p>En plus de l'inhalation, l'absorption cutanée est une voie d'exposition à prendre en compte lors de l'évaluation des risques professionnels. Pour étudier la pénétration cutanée de produits chimiques, la peau humaine est considérée comme la référence. Les échantillons humains pouvant être difficiles à obtenir, de nombreuses expériences sont réalisées sur des peaux de rat et les résultats extrapolés pour décrire l'absorption percutanée chez l'homme. Ici, nous avons examiné les caractéristiques des échantillons de peau de rat et comparé les flux d'absorption à ceux mesurés avec la peau humaine ex vivo. L’épaisseur de la couche de stratum corneum dans les échantillons de peau de rat s’est révélée stable lorsque les échantillons ont été excisés au niveau du dos d’animaux âgés d’au moins 7 semaines. Globalement, les échantillons de peau du dos de rats matures pourraient être utilisés de manière fiable pour mesurer le flux de molécules liquides hydrophiles, telles que la N-méthyl-2-pyrrolidone et le N, N-diméthylformamide. En revanche, avec une substance lipophile solide, le bisphénol A, solubilisé dans l'acétone, le flux obtenu avec des échantillons de peau de rat était 3 fois plus élevé que celui mesuré avec la peau humaine. Par conséquent, il ne semble pas pertinent d’utiliser de la peau de rat à la place de la peau humaine pour mesurer l’absorption de substances lipophiles solides.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-159664" status="VALID">
          <orgName>Institut national de recherche et de sécurité (Vandoeuvre lès Nancy)</orgName>
          <orgName type="acronym">INRS ( Vandoeuvre lès Nancy)</orgName>
          <desc>
            <address>
              <addrLine>Rue du Morvan, CS 60027, 54519 Vandœuvre Cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>