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Article Dans Une Revue Bioorganic Chemistry Année : 2020

Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds

Résumé

Two series of compounds carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivatives. The biological results revealed the efficiency of the 3-amino-1,2,4triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series (compounds 2.6 and 4.6) on several cell lines tested. Moreover, our results point out an antiangiogenic activity of these compounds. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity.
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hal-03026098 , version 1 (17-10-2022)

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Paternité - Pas d'utilisation commerciale

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Oleksandr Grytsai, Oksana Valiashko, Manon Penco-Campillo, Maeva Dufies, Anais Hagege, et al.. Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds. Bioorganic Chemistry, 2020, 104, pp.104271. ⟨10.1016/j.bioorg.2020.104271⟩. ⟨hal-03026098⟩
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