Article Dans Une Revue Genes and Development Année : 2005

Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytes

Mark Levasseur
  • Fonction : Auteur
Katie Yallop
  • Fonction : Auteur
Alison P Murdoch
  • Fonction : Auteur
Mary Herbert
  • Fonction : Auteur
Hayden A Homer
  • Fonction : Auteur

Résumé

In mitosis, the spindle checkpoint protein Mad2 averts aneuploidy by delaying anaphase onset until chromosomes align. Here we show that depletion of Mad2 in meiosis I mouse oocytes induced an increased incidence of aneuploidy. Proteolysis of cyclin B and securin commenced earlier in Mad2-depleted oocytes, resulting in a shortened duration of meiosis I. Furthermore, overexpression of Mad2 inhibited homolog disjunction. We conclude that Mad2 delays the onset of cyclin B and securin degradation and averts aneuploidy during meiosis I in mammalian oocytes. The data suggest a link between trisomies such as Down syndrome and defective oocyte spindle checkpoint function.

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hal-03025853 , version 1 (16-12-2020)

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Alex Mcdougall, Mark Levasseur, Katie Yallop, Alison P Murdoch, Mary Herbert, et al.. Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytes. Genes and Development, 2005, 19 (2), pp.202-207. ⟨10.1101/gad.328105⟩. ⟨hal-03025853⟩
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