PlexinD1 and Sema3E determine laminar positioning of heterotopically projecting callosal neurons. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Molecular and Cellular Neuroscience Année : 1970

PlexinD1 and Sema3E determine laminar positioning of heterotopically projecting callosal neurons.

Theodora Velona
  • Fonction : Auteur
Mike Altounian
  • Fonction : Auteur
Micaela Roque
  • Fonction : Auteur
Mélanie Hocine
  • Fonction : Auteur
Anaïs Bellon
  • Fonction : Auteur
Carlos Garcia Briz
  • Fonction : Auteur
Marta Nieto
  • Fonction : Auteur
Sophie Chauvet
Fanny Mann
  • Fonction : Auteur
  • PersonId : 997576
  • IdHAL : fanny-mann

Résumé

The corpus callosum is the largest bundle of commissural fibres that transfer information between the two cerebral hemispheres. Callosal projection neurons (CPNs) are a diverse population of pyramidal neurons within the neocortex that mainly interconnect homotopic regions of the opposite cortices. Nevertheless, some CPNs are involved in heterotopic projections between distinct cortical areas or to subcortical regions such as the striatum. In this study, we showed that the axon guidance receptor PlexinD1 is expressed by a large proportion of heterotopically projecting CPNs in layer 5A of the primary somatosensory (S1) and motor (M1) areas. Retrograde tracing of M1 CPNs projecting to the contralateral striatum revealed the presence of ectopic neurons aberrantly located in layers 2/3 of Plxnd1 and Sema3e mutant cortices. These results showed that Sema3E/PlexinD1 signalling controls the laminar distribution of heterotopically projecting CPNs.

Dates et versions

hal-03022316 , version 1 (24-11-2020)

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Citer

Theodora Velona, Mike Altounian, Micaela Roque, Mélanie Hocine, Anaïs Bellon, et al.. PlexinD1 and Sema3E determine laminar positioning of heterotopically projecting callosal neurons.. Molecular and Cellular Neuroscience, 1970, 100, pp.103397. ⟨10.1016/j.mcn.2019.103397⟩. ⟨hal-03022316⟩
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