A model of apoptosis receptor reactions to study cell fate decision
Résumé
The apoptotic signaling pathway designates a set of biochemical reactions involved in programmed cell death. One of the triggering mechanisms of apoptosis is the binding of death ligands to death receptors on the cell membrane, a known stimulus for the activation of the so-called extrinsic apoptosis signaling pathway. Stimulation by death ligands results in an important variability in cell response dynamics that elicits differing fates: cell survival or cell death. To understand the hallmarks of this cell fate decision and the heterogeneity of cell response, a system of ordinary differential equations based on mass-action rate laws was implemented to represent the reactions at the receptor level and evaluate the cell dynamics in response to anticancer drugs.
Domaines
- Sciences du Vivant [q-bio]
- Biologie cellulaire
- Biotechnologie
- Apprentissage [cs.LG]
- Modélisation et simulation
- Traitement des images [eess.IV]
- Traitement du signal et de l'image [eess.SP]
- Bio-Informatique, Biologie Systémique [q-bio.QM]
- Biochimie, Biologie Moléculaire
- Cancer
- Ingénierie biomédicale
- Pharmacologie
- Systèmes dynamiques [math.DS]
- Intelligence artificielle [cs.AI]
- Bio-informatique [q-bio.QM]
| Origine | Fichiers produits par l'(les) auteur(s) |
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