The purpose of this article is to report on a unique experience of bringing the topic of AIDS into a museum in France, and to describe and document the distinctive questions and practices of the museum that "exhibiting AIDS" implies. We will first present the context of the emergence of the AIDS issue in a society museum and then in the creation of a heritage fund. We will consider what stages in the history of the museum and the epidemic can be distinguished. Then we will discuss how, within a scientific committee and then in a broader community committee, we have planned to discuss the issues related to the local memory of AIDS, taking into account its global dimension, as well as the challenges involved with the museum setting.