We have probed the structural and magnetic properties of PrVO 3 (PVO) thin lms grown on the (001)-, (110)-and (111)-oriented SrTiO 3 (STO) substrates. By changing the substrate orientation, (1) the out-of-plane orientation of lm can be tuned to [110], [100] / [010], and [011] / [311], (2) the number of crystal variants in the lm can be varied, for ex. we observe single domain lm on (110)oriented STO, whereas two domains in the lm grown on the (111)-oriented STO substrate. The lattice strain induced by using dierent oriented substrates has direct inuence on the magnetic properties of PVO lms. The magnetic moment of PVO lms radically enhances from 0.4 µ B /f.u. for STO (001) to 2.3 µ B /f.u. for STO (111). While, lms on (001)-oriented STO substrate display out-of-plane anisotropy, an in-plane anisotropy is observed for lms grown on the (110)-and (111)-oriented STO substrates. In addition, a strong uniaxial magnetic anisotropy is also extracted for a partially relaxed lm on the (110)-oriented STO substrate. Such ndings can help oxide community in the better understanding of magnetic anisotropy in vanadate thin lms, a subject that still lacks scientic investigations.