The temporal evolution of individual grip force profiles of a novice using a robotic system for minimally invasive endoscopic surgery is analyzed on the basis of thousands of individual sensor data recorded in real time through a wearable wireless sensor glove system. The spatio-temporal grip force profiles from specific sensor locations in the dominant hand performing a four-step pick-and-drop simulator task reveal skill-relevant differences in force deployment by the small finger (fine grip force control) and the middle finger (gross grip force contribution) by comparison with the profiles of a highly proficient expert. Cross-disciplinary insight from systems neuroscience, cognitive behavioral science, and robotics, with implications for biologically inspired AI for human-robot interaction, highlight the functional significance of spatio-temporal grip force profiling.