The Infrared Atmospheric Sounding Interferome-ter (IASI) is an essential instrument for numerical weather prediction (NWP). It measures radiances at the top of the atmosphere using 8461 channels. The huge amount of observations provided by IASI has led the community to develop techniques to reduce observations while conserving as much information as possible. Thus, a selection of the 300 most informative channels was made for NWP based on the concept of information theory. One of the main limitations of this method was to neglect the covariances between the observation errors of the different channels. However, many centres have shown a significant benefit for weather forecasting to use them. Currently, the observation-error covariances are only estimated on the current IASI channel selection, but no studies to make a new selection of IASI channels taking into account the observation-error covariances have yet been carried out. The objective of this paper was therefore to perform a new selection of IASI channels by taking into account the observation-error covariances. The results show that with an equivalent number of channels, accounting for the observation-error covariances, a new selection of IASI channels can reduce the analysis error on average in temperature by 3 %, humidity by 1.8 % and ozone by 0.9 % compared to the current selection. Finally, we go one step further by proposing a robust new selection of 400 IASI channels to further reduce the analysis error for NWP.