Article Dans Une Revue European Journal of Organic Chemistry Année : 2019

Direct Synthesis of Thiocarbamoyl Fluorides and Trifluoromethylamines Through Fluorinative Desulfurization

Résumé

Herein, a straightforward synthesis of thiocarbamoyl fluorides is reported starting from amines and carbon disulfide. The key to success is the fluorinative desulfurization of carbon disulfide with (diethylamino)sulfurtrifluroide (DAST). The title compounds were obtained in moderate to very good isolated yields. Furthermore, we demonstrated also that thiocarbamoyl fluoride can be converted to their trifluoromethyl amine analogues through simple treatment with silver fluoride.

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hal-03008845 , version 1 (21-12-2020)

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Killian Onida, Laurent Vanoye, Anis Tlili. Direct Synthesis of Thiocarbamoyl Fluorides and Trifluoromethylamines Through Fluorinative Desulfurization. European Journal of Organic Chemistry, 2019, 2019 (35), pp.6106-6109. ⟨10.1002/ejoc.201901113⟩. ⟨hal-03008845⟩
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