Journal Articles Neurobiology of Aging Year : 2020

Resting-state posterior alpha rhythms are abnormal in subjective memory complaint seniors with preclinical Alzheimer's neuropathology and high education level: the INSIGHT-preAD study

Claudio Babiloni
Susanna Lopez
  • Function : Author
Claudio del Percio
  • Function : Author
Giuseppe Noce
  • Function : Author
Maria Teresa Pascarelli
  • Function : Author
Roberta Lizio
  • Function : Author
Stefan Teipel
  • Function : Author
Gabriel González-Escamilla
  • Function : Author
Hovagim Bakardjian
  • Function : Author
Enrica Cavedo
  • Function : Author
Simone Lista
Patrizia Andrea Chiesa
  • Function : Author
Andrea Vergallo
Pablo Lemercier
  • Function : Author
Giuseppe Spinelli
  • Function : Author
Michel Grothe
  • Function : Author
Marie-Claude Potier
Fabrizio Stocchi
  • Function : Author
Raffaele Ferri
Marie-Odile Habert
Francisco Fraga
  • Function : Author
Bruno Dubois
  • Function : Author
Harald Hampel

Abstract

Cognitive reserve is present in Alzheimer's disease (AD) seniors with high education attainment making them clinically resilient to extended brain neuropathology and neurodegeneration. Here, we tested whether subjective memory complaint (SMC) seniors with AD neuropathology and high education attainment of the prospective INSIGHT-preAD cohort (Paris) may present abnormal eyesclosed resting state posterior electroencephalographic rhythms around individual alpha frequency peak, typically altered in AD patients. The SMC participants negative to amyloid PET AD markers (SMCneg) with high (over low-moderate) education level showed higher posterior alpha 2 power density (possibly "neuro-protective"). Furthermore, amyloid PET-positive SMC (SMCpos) participants with high (over low-moderate) education level showed higher temporal alpha 3 power density (possibly "neuro-protective") and lower posterior alpha 2 power density (possibly "compensatory"). This effect may reflect cognitive reserve as no differences in brain graywhite matter, and cognitive functions were observed between these SMCpos/SMCneg subgroups. Preclinical Alzheimer's neuropathology may interact with education attainment and neurophysiological mechanisms generating cortical alpha rhythms around individual alpha frequency peak (i.e., alpha 2 and 3) in quiet wakefulness.

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hal-03006214 , version 1 (05-01-2021)

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Claudio Babiloni, Susanna Lopez, Claudio del Percio, Giuseppe Noce, Maria Teresa Pascarelli, et al.. Resting-state posterior alpha rhythms are abnormal in subjective memory complaint seniors with preclinical Alzheimer's neuropathology and high education level: the INSIGHT-preAD study. Neurobiology of Aging, 2020, 90, pp.43-59. ⟨10.1016/j.neurobiolaging.2020.01.012⟩. ⟨hal-03006214⟩
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