Biochemical and Structural Study of the Atypical Acyltransferase Domain from the Mycobacterial Polyketide Synthase Pks13
Résumé
Background: Pks13 is involved in the final biosynthesis step of mycolic acids. Results: We report the full characterization of a 52-kDa fragment containing the acyltransferase domain of Pks13. Conclusion: Pks13 is able to load unusually long chain acyl-CoAs through an unprecedented hydrophobic channel. Significance: This study could constitute a key step toward the development of new antibiotics against mycobacterial infections.
Domaines
Sciences du Vivant [q-bio]
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...