<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-03001563</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-02T18:12:32+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Ketamine induces rapid and sustained antidepressant-like effects in chronic pain induced depression: Role of MAPK signaling pathway</title>
            <author role="aut">
              <persName>
                <forename type="first">Muris</forename>
                <surname>Humo</surname>
              </persName>
              <email type="md5">1d3d900147d53ec0030ac52766ffa7bb</email>
              <email type="domain">inci-cnrs.unistra.fr</email>
              <idno type="idhal" notation="numeric">1270682</idno>
              <idno type="halauthorid" notation="string">1569144-1270682</idno>
              <affiliation ref="#struct-93782"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Beyza</forename>
                <surname>Ayazgök</surname>
              </persName>
              <email type="md5">1036530a1fa313ca2fdd38090b68e6bf</email>
              <email type="domain">inci-cnrs.unistra.fr</email>
              <idno type="idhal" notation="numeric">1312341</idno>
              <idno type="halauthorid" notation="string">2067819-1312341</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0287-1953</idno>
              <affiliation ref="#struct-65505"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Léa</forename>
                <surname>Becker</surname>
              </persName>
              <email type="md5">2ddc8c62bc3c815907559315c77b0783</email>
              <email type="domain">inci-cnrs.unistra.fr</email>
              <idno type="idhal" notation="numeric">1171729</idno>
              <idno type="halauthorid" notation="string">1678780-1171729</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5995-6088</idno>
              <idno type="IDREF">https://www.idref.fr/257840443</idno>
              <affiliation ref="#struct-93782"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Elisabeth</forename>
                <surname>Waltisperger</surname>
              </persName>
              <email type="md5">9b80a2ee637fff5187098f53718860dd</email>
              <email type="domain">inci-cnrs.unistra.fr</email>
              <idno type="idhal" notation="numeric">1513382</idno>
              <idno type="halauthorid" notation="string">162325-1513382</idno>
              <idno type="IDREF">https://www.idref.fr/257972862</idno>
              <idno type="VIAF">https://viaf.org/viaf/139163628847623461891</idno>
              <affiliation ref="#struct-93782"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Tomi</forename>
                <surname>Rantamäki</surname>
              </persName>
              <idno type="halauthorid">1147802-0</idno>
              <affiliation ref="#struct-50895"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ipek</forename>
                <surname>Yalcin</surname>
              </persName>
              <email type="md5">ae23a89694d9fe6f61b976360c70c58e</email>
              <email type="domain">inci-cnrs.unistra.fr</email>
              <idno type="idhal" notation="numeric">1302208</idno>
              <idno type="halauthorid" notation="string">315586-1302208</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2596-8598</idno>
              <idno type="IDREF">https://www.idref.fr/112849083</idno>
              <idno type="VIAF">https://viaf.org/viaf/211265368</idno>
              <idno type="ISNI">http://isni.org/isni/0000000358640652</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=CCqgybwAAAAJ</idno>
              <affiliation ref="#struct-93782"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Ipek</forename>
                <surname>Yalcin</surname>
              </persName>
              <email type="md5">ae23a89694d9fe6f61b976360c70c58e</email>
              <email type="domain">inci-cnrs.unistra.fr</email>
            </editor>
            <funder ref="#projanr-54870"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2020-11-29 19:09:24</date>
              <date type="whenModified">2026-03-04 18:51:40</date>
              <date type="whenReleased">2020-11-30 08:07:22</date>
              <date type="whenProduced">2020-06</date>
              <date type="whenEndEmbargoed">2020-11-29</date>
              <ref type="file" target="https://hal.science/hal-03001563v1/document">
                <date notBefore="2020-11-29"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-03001563v1/file/PNP_2020_accepted.pdf" id="file-3030102-2668648">
                <date notBefore="2020-11-29"/>
              </ref>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="593932">
                <persName>
                  <forename>Ipek</forename>
                  <surname>Yalcin</surname>
                </persName>
                <email type="md5">ae23a89694d9fe6f61b976360c70c58e</email>
                <email type="domain">inci-cnrs.unistra.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-03001563</idno>
            <idno type="halUri">https://hal.science/hal-03001563</idno>
            <idno type="halBibtex">humo:hal-03001563</idno>
            <idno type="halRefHtml">&lt;i&gt;Progress in Neuro-Psychopharmacology and Biological Psychiatry&lt;/i&gt;, 2020, 100, pp.109898. &lt;a target="_blank" href="https://dx.doi.org/10.1016/j.pnpbp.2020.109898"&gt;&amp;#x27E8;10.1016/j.pnpbp.2020.109898&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2020, 100, pp.109898. &amp;#x27E8;10.1016/j.pnpbp.2020.109898&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3030102-2668648"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-STRASBG">Université de Strasbourg</idno>
            <idno type="stamp" n="SITE-ALSACE">Archive ouverte du site Alsace</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="FRM">Fondation pour la Recherche Médicale</idno>
            <idno type="stamp" n="UNIVOAK">UNIVOAK</idno>
            <idno type="stamp" n="INCI">Institut des Neurosciences Cellulaires et Intégratives</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Ketamine induces rapid and sustained antidepressant-like effects in chronic pain induced depression: Role of MAPK signaling pathway</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Muris</forename>
                    <surname>Humo</surname>
                  </persName>
                  <email type="md5">1d3d900147d53ec0030ac52766ffa7bb</email>
                  <email type="domain">inci-cnrs.unistra.fr</email>
                  <idno type="idhal" notation="numeric">1270682</idno>
                  <idno type="halauthorid" notation="string">1569144-1270682</idno>
                  <affiliation ref="#struct-93782"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Beyza</forename>
                    <surname>Ayazgök</surname>
                  </persName>
                  <email type="md5">1036530a1fa313ca2fdd38090b68e6bf</email>
                  <email type="domain">inci-cnrs.unistra.fr</email>
                  <idno type="idhal" notation="numeric">1312341</idno>
                  <idno type="halauthorid" notation="string">2067819-1312341</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0287-1953</idno>
                  <affiliation ref="#struct-65505"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Léa</forename>
                    <surname>Becker</surname>
                  </persName>
                  <email type="md5">2ddc8c62bc3c815907559315c77b0783</email>
                  <email type="domain">inci-cnrs.unistra.fr</email>
                  <idno type="idhal" notation="numeric">1171729</idno>
                  <idno type="halauthorid" notation="string">1678780-1171729</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5995-6088</idno>
                  <idno type="IDREF">https://www.idref.fr/257840443</idno>
                  <affiliation ref="#struct-93782"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Elisabeth</forename>
                    <surname>Waltisperger</surname>
                  </persName>
                  <email type="md5">9b80a2ee637fff5187098f53718860dd</email>
                  <email type="domain">inci-cnrs.unistra.fr</email>
                  <idno type="idhal" notation="numeric">1513382</idno>
                  <idno type="halauthorid" notation="string">162325-1513382</idno>
                  <idno type="IDREF">https://www.idref.fr/257972862</idno>
                  <idno type="VIAF">https://viaf.org/viaf/139163628847623461891</idno>
                  <affiliation ref="#struct-93782"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Tomi</forename>
                    <surname>Rantamäki</surname>
                  </persName>
                  <idno type="halauthorid">1147802-0</idno>
                  <affiliation ref="#struct-50895"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ipek</forename>
                    <surname>Yalcin</surname>
                  </persName>
                  <email type="md5">ae23a89694d9fe6f61b976360c70c58e</email>
                  <email type="domain">inci-cnrs.unistra.fr</email>
                  <idno type="idhal" notation="numeric">1302208</idno>
                  <idno type="halauthorid" notation="string">315586-1302208</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2596-8598</idno>
                  <idno type="IDREF">https://www.idref.fr/112849083</idno>
                  <idno type="VIAF">https://viaf.org/viaf/211265368</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000358640652</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=CCqgybwAAAAJ</idno>
                  <affiliation ref="#struct-93782"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">18264</idno>
                <idno type="issn">0278-5846</idno>
                <idno type="eissn">1878-4216</idno>
                <title level="j">Progress in Neuro-Psychopharmacology and Biological Psychiatry</title>
                <imprint>
                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">100</biblScope>
                  <biblScope unit="pp">109898</biblScope>
                  <date type="datePub">2020-06</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.pnpbp.2020.109898</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Ketamine</term>
                <term xml:lang="en">Neuropathic pain-induced depression</term>
                <term xml:lang="en">Comorbidity</term>
                <term xml:lang="en">Anterior cingulate ACC</term>
                <term xml:lang="en">anterior cingulate cortex</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halDomain" n="sdv.neu">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Chronic pain produces psychologic distress, which often leads to mood disorders such as depression. Co-existing chronic pain and depression pose a serious socioeconomic burden and result in disability affecting millions individuals, which urges the development of treatment strategies targeting this comorbidity. Ketamine, a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, is shown to be efficient in treating both pain and depression-related symptoms. However, the molecular characteristics of its role in chronic pain-induced depression remain largely unexplored. Hence, we studied the behavioral and molecular effects of a single systemic administration of ketamine (15 mg/kg, i.p.) on mechanical hypersensitivity and depressive-like consequences of chronic neuropathic pain. We showed that ketamine transiently alleviated mechanical hypersensitivity (lasting &amp;lt; 24h), while its antidepressant effect was observed even 72 hours after administration. In addition, ketamine normalized the upregulated expression of the mitogen activated protein kinase (MAPK) phosphatase 1 (MKP-1) and the downregulated phosphorylation of extracellular signal-regulated kinase (pERK) in the anterior cingulate cortex (ACC) of mice displaying neuropathic pain-induced depressive-like behaviors. This effect of ketamine on the MKP-1 was first detected 30 minutes after the ketamine administration and persisted until 72h. Altogether, these findings provide insights into the behavioral and molecular changes associated with single ketamine administration in the comorbidity of chronic pain and depression.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-93782" status="VALID">
          <idno type="IdRef">157760308</idno>
          <idno type="RNSR">200918500Z</idno>
          <idno type="ROR">https://ror.org/025mhd687</idno>
          <idno type="Wikidata">Q30261396</idno>
          <orgName>Institut des Neurosciences Cellulaires et Intégratives</orgName>
          <orgName type="acronym">INCI</orgName>
          <date type="start">2009-01-01</date>
          <desc>
            <address>
              <addrLine>5 rue Blaise Pascal 67084 STRASBOURG CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://inci.u-strasbg.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-199013" type="direct"/>
            <relation name="UPR3212" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-65505" status="VALID">
          <orgName>Hacettepe University = Hacettepe Üniversitesi</orgName>
          <desc>
            <address>
              <addrLine>Hacettepe Üniversitesi Rektörlüğü Sıhhiye / ANKARA</addrLine>
              <country key="TR"/>
            </address>
            <ref type="url">https://www.hacettepe.edu.tr/english/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-50895" status="VALID">
          <idno type="IdRef">026599775</idno>
          <idno type="ROR">https://ror.org/040af2s02</idno>
          <orgName>Helsingin yliopisto = Helsingfors universitet = University of Helsinki</orgName>
          <date type="start">1919-01-01</date>
          <desc>
            <address>
              <addrLine>Yliopistonkatu 4, 00100 Helsinki</addrLine>
              <country key="FI"/>
            </address>
            <ref type="url">https://www.helsinki.fi/en</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-199013" status="VALID">
          <idno type="IdRef">131056549</idno>
          <idno type="ROR">https://ror.org/00pg6eq24</idno>
          <orgName>Université de Strasbourg</orgName>
          <orgName type="acronym">UNISTRA</orgName>
          <desc>
            <address>
              <addrLine>4 rue Blaise Pascal - CS 90032 - 67081 Strasbourg cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.unistra.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-54870" status="VALID">
          <idno type="anr">ANR-17-EURE-0022</idno>
          <orgName>EURIDOL</orgName>
          <desc>Ecole Universitaire de Recherche Interdisciplinaire sur la Douleur</desc>
          <date type="start">2017</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>