Auxin-Regulated Reversible Inhibition of TMK1 Signaling by MAKR2 Modulates the Dynamics of Root Gravitropism
Résumé
Graphical Abstract Highlights d MAKR2 is co-expressed with PIN2 and regulates the pace of root gravitropism d MAKR2 controls PIN2 asymmetric accumulation at the root level during gravitropism d MAKR2 binds to and is a negative regulator of the TMK1 receptor kinase d Auxin antagonizes the MAKR2 inhibition of TMK1 by delocalizing MAKR2 in the cytosol In Brief Marquè s-Bueno, Armengot et al. show that the unstructured protein MAKR2 controls the dynamics of the root gravitropic response by acting as a negative regulator of the TMK1 receptor kinase. In addition, the MAKR2 inhibitory effect on TMK1 signaling is antagonized by auxin itself, which triggers rapid MAKR2 membrane dissociation in a TMK1-dependent manner.
Domaines
Sciences du Vivant [q-bio]| Origine | Fichiers éditeurs autorisés sur une archive ouverte |
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