Article Dans Une Revue Synthesis: Journal of Synthetic Organic Chemistry Année : 2019

POxAP Precatalysts and the Negishi Cross-Coupling Reaction

Martine Schmitt
Frédéric Bihel

Résumé

Recently developed for the Fukuyama reaction, post-oxidative addition precatalysts (POxAPs) are also very efficient in catalyzing Negishi cross-coupling reactions between organohalides and organozinc reagents. Using very low catalyst loadings, POxAPs show similar catalytic activities to those of classical precatalysts such as XPhos Pd G4 or PEPPSI-IPr, with turnover numbers of up to 93,000. POxAPs are easily prepared, are stable to air and moisture, tolerate a wide range of functional groups in the Negishi cross-coupling reaction and contribute advantageously to the arsenal of organic chemists in terms of Pd precatalysts.

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hal-02997250 , version 1 (19-11-2020)

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Shuang-Qi Tang, Martine Schmitt, Frédéric Bihel. POxAP Precatalysts and the Negishi Cross-Coupling Reaction. Synthesis: Journal of Synthetic Organic Chemistry, 2019, 52 (01), pp.51-59. ⟨10.1055/s-0039-1690728⟩. ⟨hal-02997250⟩
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