Despite international prohibition, some ill-intentioned states and organisations have shown their will and capacity to run chemical weapon programs, and the number of incidents involving chemical warfare agents (CWA) has significantly increased in recent years. Herein, we aimed to offer a clear overview of chemical warfare agents to organic chemists not specialized in this field by (1) introducing the main CWAs and their relevant simulants legally usable in academic laboratories and (2) presenting a selection of recent and soft neutralisation methods, such as organocatalysis and continuous flow, and materials such as metal–organic frameworks and polyoxometalates. These modern approaches offer potential future alternatives to “heavy” decontamination methods.