Thyroid hormone receptor α in skeletal muscle is essential for T3‐mediated increase in energy expenditure - Archive ouverte HAL
Article Dans Une Revue FASEB Journal Année : 2020

Thyroid hormone receptor α in skeletal muscle is essential for T3‐mediated increase in energy expenditure

Résumé

HIGHLIGHTS • Thyroid hormone receptor alpha 1 (TRa1) is critical for fiber type composition in slow twitch muscle. • TRa1 loss-of-function in skeletal muscle does not affect exercise capacity or voluntary running. • In the absence of muscle TRa1, increased sarcolipin expression might safeguard basal metabolic rate and exercise capacity. • Thyroid hormone-induced increase in metabolic rate (thyroid thermogenesis) is dependent on TRa1 in skeletal muscle. • Thyroid hormone-induced elevation in body temperature is independent of skeletal muscle TRa1.
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Dates et versions

hal-02996920 , version 1 (20-11-2020)

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Trine S Nicolaisen, Anders B Klein, Oksana Dmytriyeva, Jens Lund, Lars R Ingerslev, et al.. Thyroid hormone receptor α in skeletal muscle is essential for T3‐mediated increase in energy expenditure. FASEB Journal, 2020, 34 (11), pp.15480-15491. ⟨10.1096/fj.202001258RR⟩. ⟨hal-02996920⟩
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