Mn(II)-based MRI contrast agent candidate for vascular imaging
Résumé
Toxicity concerns related to Gd(III)-based magnetic resonance imaging (MRI) agents prompted an intensive research toward their replacement by complexes of essential metal ions, like Mn(II). Here, we report a macrocyclic chelate, [Mn(PC2A-BP)], which possesses high thermodynamic stability (log K MnL = 14.86 and pMn=8.35) and kinetic inertness (t 1/2 pH=7.4 = 286.2 h) as well as as remarkable relaxivity (r 1p = 23.5 mM −1 s −1 , 0.49 T, 37°C) in the presence of human serum albumin, allowing a significant MRI signal intensity increase in the vasculature even at low dose (25 μmol/kg) of the complex.
Domaines
Imagerie| Origine | Fichiers produits par l'(les) auteur(s) |
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