Communication Dans Un Congrès Année : 2018

Nanoparticles for X-ray-Induced PDT

Résumé

Photodynamic therapy (PDT) is a cancer therapy modality. After excitation of a photo-activable molecule called the photosensitizer and energy transfer to oxygen, reactive oxygen species are produced leading to photooxidation reactions. New improvements in the field of PDT concern the development of nanoparticles that can work as carrier for anti-cancer agent delivery. They have indeed many advantages such as good colloidal stability, effective protection of encapsulated drug against enzymes and hydrolysis, surface tailorability and multifunctionality, and relatively easy preparation. Moreover, thanks to their small size, nanoparticles are a mean to allow selective accumulation of the PS in cancer cells due to the enhanced permeability and retention (EPR) effect of tumor tissues [1, 2]. One of the limit of PDT is the low penetration of light into the tissue. Recent publications and our results lead us to suggest the development of nanoparticles excited by radiotherapy (standard X-ray from an external corporal energy source) for the treatment of malignant cerebral gliomas [3, 4]. Novel hybrid system of scintillating nanoparticles (nanoscintillators) and PDT photosensitizers enabling excitation of the constructed nanodevices using by X-rays, which can penetrate deeply into tissues. Upon exposure to ionizing radiation nanoscintillators transfer its energy to the photosensitizers resulting in their activation. With this novel therapeutic approach, limited light penetration problem could be overcome and activation of the photosensitizer within tumours could be performed using ionizing radiation. This new modality could allow treatment of deep tumours using lower radiation dose than conventional radiotherapy. REFERENCES 1. Bechet, D., Couleaud, P., Frochot, C., Viriot, M.L., Barberi-Heyob, M., Trends in Biotechnology, 2008, 26, 612-621. 2. Couleaud, P., Bechet, D., Vanderesse, R., Barberi-Heyob, M., Faure, A.C., Roux S., Tillement, O., Porhel S., Guillemin F., Frochot C., Nanomedicine, 2011, 6(6), 995-1009. 3. Bulin, A.L., Truillet, C., Chouikrat, R., Lux, F., Frochot, C., Amans, D., Ledoux, G., Tillement, O., Perriat, P., Barberi-Heyob, M., Dujardin, C., J Phys Chem C, 2013, 117(41), 21583-21589. 4. Rétif P., Pinel S., Toussaint M., Frochot C., Chouikrat R., Bastogne T., Barberi-Heyob M., Theranostic, 2015, 5(9), 1030-1044. 5. Chouikrat R., Baros F., André J.C., Vanderesse R., Viana B., Bulin A.L., Dujardin C., Arnoux P., Verelst M., Frochot C., Photochemistry and Photobiology, 2017, 93(6), 1439–1448.

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Dates et versions

hal-02994644 , version 1 (08-11-2020)

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  • HAL Id : hal-02994644 , version 1

Citer

Céline Frochot, Francis Baros, Philippe Arnoux, Samir Acherar, Paul Retif, et al.. Nanoparticles for X-ray-Induced PDT. International Conference on Porphyrins and Phthalocyanines, ICCP-10, Jul 2018, Munich, Germany. ⟨hal-02994644⟩
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