<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02992864</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-22T06:31:52+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Tuning Size and Morphology of mPEG-b-p(HPMA-Bz) Copolymer Self-Assemblies Using Microfluidics</title>
            <author role="aut">
              <persName>
                <forename type="first">Jaleesa</forename>
                <surname>Bresseleers</surname>
              </persName>
              <idno type="halauthorid">1458858-0</idno>
              <affiliation ref="#struct-4629"/>
              <affiliation ref="#struct-1055551"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mahsa</forename>
                <surname>Bagheri</surname>
              </persName>
              <idno type="halauthorid">1458857-0</idno>
              <affiliation ref="#struct-93078"/>
              <affiliation ref="#struct-300572"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Coralie</forename>
                <surname>Lebleu</surname>
              </persName>
              <idno type="halauthorid">1665133-0</idno>
              <affiliation ref="#struct-247140"/>
              <affiliation ref="#struct-390355"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sébastien</forename>
                <surname>Lecommandoux</surname>
              </persName>
              <email type="md5">bbc5d8f8786c0464551ffc833928ec63</email>
              <email type="domain">enscbp.fr</email>
              <idno type="idhal" notation="numeric">829909</idno>
              <idno type="halauthorid" notation="string">103919-829909</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0465-8603</idno>
              <idno type="IDREF">https://www.idref.fr/102556040</idno>
              <affiliation ref="#struct-247140"/>
              <affiliation ref="#struct-390355"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Olivier</forename>
                <surname>Sandre</surname>
              </persName>
              <email type="md5">a7778571e05a01f4601f292b1f121ecd</email>
              <email type="domain">enscbp.fr</email>
              <idno type="idhal" notation="string">olivier-sandre</idno>
              <idno type="idhal" notation="numeric">306</idno>
              <idno type="halauthorid" notation="string">36255-306</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/H-3213-2011</idno>
              <idno type="IDREF">https://www.idref.fr/183876504</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1815-2702</idno>
              <idno type="VIAF">https://viaf.org/viaf/314927442</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=4FfMj7YAAAAJ</idno>
              <affiliation ref="#struct-247140"/>
              <affiliation ref="#struct-390355"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Imke A. B.</forename>
                <surname>Pijpers</surname>
              </persName>
              <idno type="halauthorid">2061440-0</idno>
              <affiliation ref="#struct-4629"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alexander F.</forename>
                <surname>Mason</surname>
              </persName>
              <idno type="halauthorid">2061441-0</idno>
              <affiliation ref="#struct-4629"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Silvie</forename>
                <surname>Meeuwissen</surname>
              </persName>
              <idno type="halauthorid">2061442-0</idno>
              <affiliation ref="#struct-1055551"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Cornelus F. Van</forename>
                <surname>Nostrum</surname>
              </persName>
              <idno type="halauthorid">2061443-0</idno>
              <affiliation ref="#struct-93078"/>
              <affiliation ref="#struct-300572"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Wim E.</forename>
                <surname>Hennink</surname>
              </persName>
              <idno type="halauthorid">2061444-0</idno>
              <affiliation ref="#struct-93078"/>
              <affiliation ref="#struct-300572"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Jan C. M. Van</forename>
                <surname>Hest</surname>
              </persName>
              <idno type="halauthorid">2062779-0</idno>
              <affiliation ref="#struct-4629"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Oskar</forename>
                <surname>Admin</surname>
              </persName>
              <email type="md5">d49c5a880544a575d14059bbcdef4ae8</email>
              <email type="domain">oskar-bordeaux.fr</email>
            </editor>
            <funder ref="#projeurop-135641"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2020-11-09 10:08:55</date>
              <date type="whenModified">2025-11-23 18:10:32</date>
              <date type="whenReleased">2020-11-20 08:36:09</date>
              <date type="whenProduced">2020-11-02</date>
              <date type="whenEndEmbargoed">2020-11-09</date>
              <ref type="file" target="https://hal.science/hal-02992864v1/document">
                <date notBefore="2020-11-09"/>
              </ref>
              <ref type="file" subtype="greenPublisher" n="1" target="https://hal.science/hal-02992864v1/file/Bresseleers_et_al_Polymers-12-02572_with_ESI.pdf" id="file-2995335-2637677">
                <date notBefore="2020-11-09"/>
              </ref>
              <ref type="externalLink" target="https://doi.org/10.3390/polym12112572"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="851509">
                <persName>
                  <forename>Oskar</forename>
                  <surname>Admin</surname>
                </persName>
                <email type="md5">d49c5a880544a575d14059bbcdef4ae8</email>
                <email type="domain">oskar-bordeaux.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02992864</idno>
            <idno type="halUri">https://hal.science/hal-02992864</idno>
            <idno type="halBibtex">bresseleers:hal-02992864</idno>
            <idno type="halRefHtml">&lt;i&gt;Polymers&lt;/i&gt;, 2020, 12 (11), pp.2572. &lt;a target="_blank" href="https://dx.doi.org/10.3390/polym12112572"&gt;&amp;#x27E8;10.3390/polym12112572&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Polymers, 2020, 12 (11), pp.2572. &amp;#x27E8;10.3390/polym12112572&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-2995335-2637677"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="OPENAIRE">OpenAIRE</idno>
            <idno type="stamp" n="INC-CNRS">Institut de Chimie du CNRS</idno>
            <idno type="stamp" n="TEST-HALCNRS">Collection test HAL CNRS</idno>
            <idno type="stamp" n="LCPO">Laboratoire de Chimie des Polymères Organiques</idno>
            <idno type="stamp" n="TEST2-HALCNRS">TEST2-HALCNRS</idno>
            <idno type="stamp" n="UNIVERSITE-BORDEAUX">Université de Bordeaux</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Tuning Size and Morphology of mPEG-b-p(HPMA-Bz) Copolymer Self-Assemblies Using Microfluidics</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Jaleesa</forename>
                    <surname>Bresseleers</surname>
                  </persName>
                  <idno type="halauthorid">1458858-0</idno>
                  <affiliation ref="#struct-4629"/>
                  <affiliation ref="#struct-1055551"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mahsa</forename>
                    <surname>Bagheri</surname>
                  </persName>
                  <idno type="halauthorid">1458857-0</idno>
                  <affiliation ref="#struct-93078"/>
                  <affiliation ref="#struct-300572"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Coralie</forename>
                    <surname>Lebleu</surname>
                  </persName>
                  <idno type="halauthorid">1665133-0</idno>
                  <affiliation ref="#struct-247140"/>
                  <affiliation ref="#struct-390355"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sébastien</forename>
                    <surname>Lecommandoux</surname>
                  </persName>
                  <email type="md5">bbc5d8f8786c0464551ffc833928ec63</email>
                  <email type="domain">enscbp.fr</email>
                  <idno type="idhal" notation="numeric">829909</idno>
                  <idno type="halauthorid" notation="string">103919-829909</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0465-8603</idno>
                  <idno type="IDREF">https://www.idref.fr/102556040</idno>
                  <affiliation ref="#struct-247140"/>
                  <affiliation ref="#struct-390355"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Olivier</forename>
                    <surname>Sandre</surname>
                  </persName>
                  <email type="md5">a7778571e05a01f4601f292b1f121ecd</email>
                  <email type="domain">enscbp.fr</email>
                  <idno type="idhal" notation="string">olivier-sandre</idno>
                  <idno type="idhal" notation="numeric">306</idno>
                  <idno type="halauthorid" notation="string">36255-306</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/H-3213-2011</idno>
                  <idno type="IDREF">https://www.idref.fr/183876504</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1815-2702</idno>
                  <idno type="VIAF">https://viaf.org/viaf/314927442</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=4FfMj7YAAAAJ</idno>
                  <affiliation ref="#struct-247140"/>
                  <affiliation ref="#struct-390355"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Imke A. B.</forename>
                    <surname>Pijpers</surname>
                  </persName>
                  <idno type="halauthorid">2061440-0</idno>
                  <affiliation ref="#struct-4629"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alexander F.</forename>
                    <surname>Mason</surname>
                  </persName>
                  <idno type="halauthorid">2061441-0</idno>
                  <affiliation ref="#struct-4629"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Silvie</forename>
                    <surname>Meeuwissen</surname>
                  </persName>
                  <idno type="halauthorid">2061442-0</idno>
                  <affiliation ref="#struct-1055551"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Cornelus F. Van</forename>
                    <surname>Nostrum</surname>
                  </persName>
                  <idno type="halauthorid">2061443-0</idno>
                  <affiliation ref="#struct-93078"/>
                  <affiliation ref="#struct-300572"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Wim E.</forename>
                    <surname>Hennink</surname>
                  </persName>
                  <idno type="halauthorid">2061444-0</idno>
                  <affiliation ref="#struct-93078"/>
                  <affiliation ref="#struct-300572"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Jan C. M. Van</forename>
                    <surname>Hest</surname>
                  </persName>
                  <idno type="halauthorid">2062779-0</idno>
                  <affiliation ref="#struct-4629"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">115252</idno>
                <idno type="issn">2073-4360</idno>
                <title level="j">Polymers</title>
                <imprint>
                  <publisher>MDPI</publisher>
                  <biblScope unit="volume">12</biblScope>
                  <biblScope unit="issue">11</biblScope>
                  <biblScope unit="pp">2572</biblScope>
                  <date type="datePub">2020-11-02</date>
                </imprint>
              </monogr>
              <idno type="doi">10.3390/polym12112572</idno>
              <idno type="pubmed">33147743</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">micromixer</term>
                <term xml:lang="en">HPMA</term>
                <term xml:lang="en">polymersomes</term>
                <term xml:lang="en">micelles</term>
                <term xml:lang="en">block copolymers</term>
                <term xml:lang="en">microfluidics</term>
                <term xml:lang="en">nanoparticles</term>
                <term xml:lang="en">nanoprecipitation</term>
                <term xml:lang="en">size control</term>
              </keywords>
              <classCode scheme="halDomain" n="chim.mate">Chemical Sciences/Material chemistry</classCode>
              <classCode scheme="halDomain" n="chim.poly">Chemical Sciences/Polymers</classCode>
              <classCode scheme="halDomain" n="sdv.sp">Life Sciences [q-bio]/Pharmaceutical sciences</classCode>
              <classCode scheme="halDomain" n="phys.cond.cm-scm">Physics [physics]/Condensed Matter [cond-mat]/Soft Condensed Matter [cond-mat.soft]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The careful design of nanoparticles, in terms of size and morphology, is of great importance to developing effective drug delivery systems. The ability to precisely tailor nanoparticles in size and morphology during polymer self-assembly was therefore investigated. Four poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) mPEG-b-p(HPMA-Bz) block copolymers with a fixed hydrophilic block of mPEG 5 kDa and a varying molecular weight of the hydrophobic p(HPMA-Bz) block (A: 17.1, B: 10.0, C: 5.2 and D: 2.7 kDa) were self-assembled into nanoparticles by nanoprecipitation under well-defined flow conditions, using microfluidics, at different concentrations. The nanoparticles from polymer A, increased in size from 55 to 90 nm using lower polymer concentrations and slower flow rates and even polymer vesicles were formed along with micelles. Similarly, nanoparticles from polymer D increased in size from 35 to 70 nm at slower flow rates and also formed vesicles along with micelles, regardless of the used concentration. Differently, polymers B and C mainly self-assembled into micelles at the different applied flow rates with negligible size difference. In conclusion, this study demonstrates that the self-assembly of mPEG-b-p(HPMA-Bz) block copolymers can be easily tailored in size and morphology using microfluidics and is therefore an attractive option for further scaled-up production activities.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-4629" status="VALID">
          <idno type="IdRef">03247508X</idno>
          <idno type="ISNI">0000 0004 0398 8763</idno>
          <idno type="ROR">https://ror.org/02c2kyt77</idno>
          <idno type="Wikidata">Q280824</idno>
          <orgName>Eindhoven University of Technology [Eindhoven]</orgName>
          <orgName type="acronym">TU/e</orgName>
          <desc>
            <address>
              <addrLine>Technische Universiteit Eindhoven - Den Dolech 2 5612 AZ Eindhoven</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">https://www.tue.nl/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1055551" status="INCOMING">
          <orgName>Ardena</orgName>
          <desc>
            <address>
              <addrLine>5349 AB Oss, The Netherlands</addrLine>
              <country key="NL"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-93078" status="INCOMING">
          <orgName>Department of Pharmaceutics Utrecht Institute for Pharmaceutical Sciences</orgName>
          <orgName type="acronym">UIPS</orgName>
          <desc>
            <address>
              <addrLine>Utrecht University PO Box 80082, 3508 TB, Utrecht</addrLine>
              <country key="NL"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300572" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300572" status="VALID">
          <idno type="ROR">https://ror.org/04pp8hn57</idno>
          <orgName>Universiteit Utrecht / Utrecht University [Utrecht]</orgName>
          <desc>
            <address>
              <addrLine>Heidelberglaan 8, 3584 CS Utrecht</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">http://www.uu.nl/en</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-247140" status="VALID">
          <idno type="ISNI">0000000403847151</idno>
          <idno type="RNSR">198612058X</idno>
          <idno type="ROR">https://ror.org/056n05x05</idno>
          <orgName>Laboratoire de Chimie des Polymères Organiques</orgName>
          <orgName type="acronym">LCPO</orgName>
          <date type="start">2014-01-01</date>
          <desc>
            <address>
              <addrLine>16, Avenue Pey Berland 33607 PESSAC CEDEX</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.lcpo.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-259761" type="direct"/>
            <relation active="#struct-301490" type="direct"/>
            <relation active="#struct-301962" type="direct"/>
            <relation active="#struct-341038" type="direct"/>
            <relation name="UMR5629" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-390355" status="VALID">
          <orgName>Team 3 LCPO : Polymer Self-Assembly &amp; Life Sciences</orgName>
          <desc>
            <address>
              <addrLine>ENSCBP, 16 Avenue Pey Berland, 33600 Pessac</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.lcpo.fr/research/teams/polymer-self-assembly-and-life-sciences</ref>
          </desc>
          <listRelation>
            <relation active="#struct-247140" type="direct"/>
            <relation active="#struct-259761" type="indirect"/>
            <relation active="#struct-301490" type="indirect"/>
            <relation active="#struct-301962" type="indirect"/>
            <relation active="#struct-341038" type="indirect"/>
            <relation name="UMR5629" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-259761" status="VALID">
          <idno type="IdRef">175206562</idno>
          <idno type="ROR">https://ror.org/057qpr032</idno>
          <orgName>Université de Bordeaux</orgName>
          <orgName type="acronym">UB</orgName>
          <desc>
            <address>
              <addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.u-bordeaux.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301490" status="VALID">
          <orgName>École Nationale Supérieure de Chimie, de Biologie et de Physique</orgName>
          <orgName type="acronym">ENSCBP</orgName>
          <desc>
            <address>
              <addrLine>16 Av. Pey Berland, 33600 Pessac</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://ensmac.bordeaux-inp.fr/fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301962" status="VALID">
          <idno type="ROR">https://ror.org/054qv7y42</idno>
          <orgName>Institut Polytechnique de Bordeaux</orgName>
          <desc>
            <address>
              <addrLine>146, rue Léo Saignat, 33076 Bordeaux</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="europeanProject" xml:id="projeurop-135641" status="VALID">
          <idno type="number">676137</idno>
          <idno type="program">H2020-MSCA-ITN-2015</idno>
          <idno type="call">H2020-MSCA-ITN-2015</idno>
          <orgName>NANOMED</orgName>
          <desc>Nanomedicine: an integrative approach</desc>
          <date type="start">2016-01-01</date>
          <date type="end">2019-12-31</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>